Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM64ZYM)

Drug Name

GPI-1485 Drug Info

Synonyms

186268-78-0; GPI-1485; UNII-0709BVY57W; (2S)-1-(3,3-dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylic acid; (2S)-1-(1,2-DIOXO-3,3-DIMETHYLPENTYL)-2-PYRROLIDINECARBOXYLIC ACID; 0709BVY57W; (S)-1-(3,3-Dimethyl-2-oxopentanoyl)pyrrolidine-2-carboxylic acid; L-Proline, 1-(3,3-dimethyl-1,2-dioxopentyl)-; GPI 1485; SCHEMBL2006950; CTK6C7007; FOPALECPEUVCTL-QMMMGPOBSA-N; MolPort-023-219-569; ZX-RL003437; 1-(1,2-Dioxo-3,3-dimethylpentyl)-2-pyrrolidine carboxylic acid, 2S; ZINC33979157; 6256AD; AKOS015991368; DB05814; EG-0058

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Phase 2	[1]

Cross-matching ID

PubChem CID: 9837656
CAS Number: CAS 186268-78-0
TTD Drug ID: DM64ZYM

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting FK506-binding protein 1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SDZ-281-240	DMPZ67G	Pruritus	EC90	Phase 2	[3]
AP1903	DM2LU8M	Transplant rejection	NE84	Phase 1/2	[4]
Gpi-1046	DMD5WK4	Parkinson disease	8A00.0	Terminated	[5]
MYRISTIC ACID	DMYX0BL	Discovery agent	N.A.	Investigative	[5]
Heptyl-Beta-D-Glucopyranoside	DMPQBN0	Discovery agent	N.A.	Investigative	[6]
4-Hydroxy-2-Butanone	DM7BQ65	Discovery agent	N.A.	Investigative	[7]
L-709,587	DM9KCYQ	Discovery agent	N.A.	Investigative	[7]
Methyl Methylsulfinylmethyl Sulfide	DMOCXLW	Discovery agent	N.A.	Investigative	[7]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[7]
FKB-001	DM9K834	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
FK506-binding protein 1A (FKBP1A)	TTMW94E	FKB1A_HUMAN	Binder	[2]

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References

1	Emerging drugs for Parkinson's disease. Expert Opin Emerg Drugs. 2006 Sep;11(3):403-17.
2	Drugs used to treat Parkinson's disease, present status and future directions. CNS Neurol Disord Drug Targets. 2008 Oct;7(4):321-42.
3	Clearing of psoriasis by a novel immunosuppressive macrolide. J Invest Dermatol. 1996 Apr;106(4):701-10.
4	Using gene transfer to circumvent off-target effects. Gene Ther. 2008 May;15(10):759-64.
5	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
6	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.