Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM69MKU)

Drug Name

F3 Drug Info

Synonyms

1-Chloro-1,2,2-trifluorocyclobutane; 661-71-2; Cyclobutane, 1-chloro-1,2,2-trifluoro-; 1-Ctfcb; AC1Q4KXO; AC1L2WN1; GTPL2400; SCHEMBL3123282; CTK5C3598; MolPort-001-773-111; ZX-AP007208; 7606AE; PC2028; 7607AE; FCH917920; SBB086362; MFCD00042139; AKOS006230600; Cyclobutane,1-chloro-1,2,2-trifluoro-; TR-022419; FT-0607576; C-47497; I14-28177

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 79091
CAS Number: CAS 661-71-2
TTD Drug ID: DM69MKU
VARIDT Drug ID: DR01109

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Inward rectifier potassium channel Kir3.2 (KCNJ6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PIP2	DMOZV7N	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inward rectifier potassium channel Kir3.2 (KCNJ6)	TTTIBVP	KCNJ6_HUMAN	Inhibitor (gating inhibitor)	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2400).
2	Differential effects of general anesthetics on G protein-coupled inwardly rectifying and other potassium channels. Anesthesiology. 2001 Jul;95(1):144-53.
3	Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature. 1998 Feb 19;391(6669):803-6.