Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6F5EV)

Drug Name

PD-360324 Drug Info

Synonyms

PD-0360324; MCSF mAb (RA), Pfizer; Macrophage colony stimulating factor monoclonal antibody (rheumatoid arthritis), Pfizer

Indication

Disease Entry	ICD 11	Status	REF
Rheumatoid arthritis	FA20	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Colony stimulating factor-1 receptor (CSF-1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ARRY-382	DM0VGDC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[3]
RG7155	DM8JMNL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[4]
MCS-110	DM0CL4I	Bone metastases	2D50	Phase 2	[5]
JNJ-40346527	DM219SF	Hodgkin lymphoma	2B30	Phase 2	[6]
FPA-008	DM3ZN6Y	Autoimmune diabetes	5A10	Phase 1/2	[7]
AMG 820	DMB6Q19	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
IMC-CS4	DMUYN26	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Colony stimulating factor-1 receptor (CSF-1R)	TT731LW	E9PEK4_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01732211) A Phase 2, Safety, Tolerability, and Efficacy Study of PD 0360324 in Chronic Pulmonary Sarcoidosis. U.S. National Institutes of Health.
2	Monoclonal antibody against macrophage colony-stimulating factor suppresses circulating monocytes and tissue macrophage function but does not alter cell infiltration/activation in cutaneous lesions or clinical outcomes in patients with cutaneous lupus erythematosus.Clin Exp Immunol.2016 Feb;183(2):258-70.
3	Company report (Array)
4	Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell. 2014 Jun 16;25(6):846-59.
5	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
6	An Open-Label, Multicenter, Phase I/II Study of JNJ-40346527, a CSF-1R Inhibitor, in Patients with Relapsed or Refractory Hodgkin Lymphoma. Clin Cancer Res. 2015 Apr 15;21(8):1843-50.
7	Company report (Five Prime Therapeutics)