Details of the Drug-Related molecule(s) Interaction Atlas

US9623028, Compound 101 Drug Info

SCHEMBL15880506; CHEMBL4099734; BDBM317468; US9623028, Compound 101; 4-(4-(cyclopentyloxy)-5-(2- methylbenzo[d]oxazol-6-yl)-7H- pyrrolo[2,3-d]pyrimidin-2- ylamino)-N-(2-hydroxyethyl)-3- methoxybenzamide

Cross-matching ID

PubChem CID

90285039

TTD Drug ID

DM6F7M2

General Information of Drug (ID: DM6F7M2)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

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Drug(s) Targeting Calmodulin-dependent kinase II (CAMKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CQ7	DMXP073	N. A.	N. A.	Patented	[1]
US9623028, Compound 79	DMMSHX4	N. A.	N. A.	Patented	[1]
PMID22136433C20	DMI8217	Discovery agent	N.A.	Investigative	[2]
STO609	DMZSOG2	Discovery agent	N.A.	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calmodulin-dependent kinase II (CAMKK2)	TTV298Y	KKCC2_HUMAN	Inhibitor	[1]

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References

1	Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof. US9623028.
2	7,8-dichloro-1-oxo-beta-carbolines as a versatile scaffold for the development of potent and selective kinase inhibitors with unusual binding modes. J Med Chem. 2012 Jan 12;55(1):403-13.
3	STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase. J Biol Chem. 2002 May 3;277(18):15813-8.