Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6GE21)

Drug Name
Sapropterin Drug Info
Synonyms
L-erythro-tetrahydrobiopterin; R-THBP; Sapropterin; Sapropterin (INN); Sapropterin [INN]; Sapropterina; Sapropterinum; tetrahydro-l-biopterin; (6R)-2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one; (6R)-L-erythro-tetrahydrobiopterin; 2-Amino-6-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydoro-4(1H)-pteridinone; 62989-33-7; 6R-5,6,7,8-Tetrahydrobiopterin; 6R-BH4; 6R-L-5,6,7,8-Tetrahydrobiopterin; Kuvan; UNII-EGX657432I
Indication
Disease Entry ICD 11 Status REF
Phenylketonuria 5C50.0 Approved [1]
Cross-matching ID
PubChem CID
135398654
ChEBI ID
CHEBI:59560
CAS Number
CAS 62989-33-7
TTD Drug ID
DM6GE21
INTEDE Drug ID
DR2017

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DME
Drug Status:
Approved Drug(s)
Download the Complete Related Drug List
Drug(s) Metabolized By Tryptophan 5-hydroxylase 2 (TPH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-Tryptophan DMIBH7M Depression 6A70-6A7Z Approved [3]
Tetrahydrobiopterin DMINZ4W Malnutrition 5B50-5B71 Approved [2]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Tryptophan 5-hydroxylase 2 (TPH2) Main DME DER6XYF TPH2_HUMAN Substrate [2]

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. J Neurochem. 2007 Mar;100(6):1648-57.
3 Strain differences in basal and post-citalopram extracellular 5-HT in the mouse medial prefrontal cortex and dorsal hippocampus: relation with tryptophan hydroxylase-2 activity. J Neurochem. 2007 Nov;103(3):1111-20.