Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6HPEC)

Drug Name

USL311 Drug Info

Synonyms

Usl-311; UNII-2BTG5MX2Q2; 2BTG5MX2Q2; SCHEMBL15347153; USL-311; 2-Pyridinecarboxamide, 6-(hexahydro-4-(1-(1-methylethyl)-4-piperidinyl)-1H-1,4-diazepin-1-yl)-N-4-pyridinyl-; 1373268-67-7

Indication

Disease Entry	ICD 11	Status	REF
Recurring respiratory infection	CA07-CA45	Phase 1/2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 56961879
CAS Number: CAS 1373268-67-7
TTD Drug ID: DM6HPEC

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Plerixafor	DMCJN1P	Non-hodgkin lymphoma	2B33.5	Approved	[2]
Motixafortide	DMW34B1	Multiple myeloma	2A83	Approved	[3]
Ulocuplumab	DM6PMNR	Multiple myeloma	2A83	Phase 3	[4]
Balixafortide	DMUOFAC	Metastatic breast cancer	2C6Y	Phase 3	[5]
AMD-070	DMVOY6B	Whim syndrome	4A00.Y	Phase 3	[6]
TG-0054	DM2ZLWH	Macular degeneration	9B78.3	Phase 2	[7]
POL-6326	DM4OT29	Human immunodeficiency virus infection	1C62	Phase 2	[8]
CTCE-9908	DM95XR8	Sarcoma	2A60-2C35	Phase 1/2	[9]
GMI-1359	DML1KSA	Breast cancer	2C60-2C65	Phase 1	[10]
ALX-0651	DMIRYM8	Haematological malignancy	2B33.Y	Phase 1	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-X-C chemokine receptor type 4 (CXCR4)	TTBID49	CXCR4_HUMAN	Antagonist	[1]

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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
3	The CXCR4 Antagonist BL-8040 Efficiently Induces Apoptosis and Inhibits The Survival Of AML Cells. November 15, 2013; Blood: 122 (21).
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Anti-ageing pipeline starts to mature.Nat Rev Drug Discov. 2018 Sep;17(9):609-612.
6	Pharmacokinetic effect of AMD070, an Oral CXCR4 antagonist, on CYP3A4 and CYP2D6 substrates midazolam and dextromethorphan in healthy volunteers. J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):559-65.
7	CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28.
8	CXCR4 inhibitors: tumor vasculature and therapeutic challenges. Recent Pat Anticancer Drug Discov. 2012 Sep;7(3):251-64.
9	A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res. 2009 Aug;155(2):231-6.
10	Clinical pipeline report, company report or official report of GlycoMimetics.
11	Therapeutic antibodies directed at G protein-coupled receptors. MAbs. 2010 Nov-Dec; 2(6): 594-606.