Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6L5ZQ)

Drug Name

Vercirnon Drug Info

Synonyms

1605786

Indication

Disease Entry	ICD 11	Status	REF
Crohn disease	DD70	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting C-C chemokine receptor type 9 (CCR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CCX-025	DMCWVS7	Crohn disease	DD70	Phase 1	[3]
CCX507	DMO7TES	Ulcerative colitis	DD71	Phase 1	[4]
MLN-3126	DMDB3OK	Sjogren syndrome	4A43.20	Phase 1	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
C-C chemokine receptor type 9 (CCR9)	TTIPS8B	CCR9_HUMAN	Modulator	[2]

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References

1	ClinicalTrials.gov (NCT01536418) An Active Treatment Study to Induce Clinical Response and/or Remission With GSK1605786A in Subjects With Crohn's Disease. U.S. National Institutes of Health.
2	GSK-1605786, a selective small-molecule antagonist of the CCR9 chemokine receptor for the treatment of Crohn's disease. IDrugs. 2010 Jul;13(7):472-81.
3	Targeting T-cell migration in inflammatory bowel disease. J Intern Med. 2012 Nov;272(5):411-29.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)