Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6QT9P)

Drug Name

BIBB-515 Drug Info

Synonyms

BIBB 515; BIBB-515; 156635-05-1; UNII-CG2Q6688S4; CHEMBL417571; CG2Q6688S4; (4-Chloro-phenyl)-{4-[4-(4,5-dihydro-oxazol-2-yl)-benzylidene]-piperidin-1-yl}-methanone; (4-chloro-phenyl)-(4-[4-(4,5-dihydro-oxazol-2-yl)-benzylidene]-piperidin-1-yl)-methanone; AC1L9UY8; SCHEMBL3676833; CTK8E8258; DTXSID00333401; MolPort-009-019-333; ZINC598970; BDBM50128071; RT-011501; J-009325; 1-(4-Chlorobenzoyl)-4-((4-(2-oxazolin-2-yl) benzylidene))piperidine; Piperidine, 1-(4-chlorobenzoyl)-4-((4-(4,5-dihydro-2-oxazolyl)phenyl)methylene)-

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Terminated	[1]

Cross-matching ID

PubChem CID: 501398
CAS Number: CAS 156635-05-1
TTD Drug ID: DM6QT9P

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Discontinued Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ZD-9720	DMFV47R	Arteriosclerosis	BD40	Terminated	[2]
BIBX-79	DMRXWCO	Arteriosclerosis	BD40	Terminated	[3]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[4]
Lanosterol	DMHN74V	Discovery agent	N.A.	Investigative	[4]
PMID22533316C1	DMYEMWB	Discovery agent	N.A.	Investigative	[5]
PMID22533316C4	DMW3UHO	Discovery agent	N.A.	Investigative	[5]
PMID9003518C4	DMYE64O	Discovery agent	N.A.	Investigative	[6]
29-methylidene-2,3-oxidosqualene	DMUQAP7	Discovery agent	N.A.	Investigative	[6]
Tetradecane	DMK8P61	Discovery agent	N.A.	Investigative	[4]
PMID9003518C3	DM1I578	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lanosterol synthase (LSS)	TT7O8ZA	ERG7_HUMAN	Modulator	[1]

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References

1	Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo. J Lipid Res. 1997 Mar;38(3):564-75.
2	Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse. Toxicol Pathol. 2001 Mar-Apr;29(2):174-9.
3	Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells. J Lipid Res. 1996 Jan;37(1):148-58.
4	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
5	Cytotoxic effects of combination of oxidosqualene cyclase inhibitors with atorvastatin in human cancer cells. J Med Chem. 2012 Jun 14;55(11):4990-5002.
6	Synthesis and inhibition studies of sulfur-substituted squalene oxide analogues as mechanism-based inhibitors of 2,3-oxidosqualene-lanosterol cyclase. J Med Chem. 1997 Jan 17;40(2):201-9.