General Information of Drug (ID: DM6XJ9S)

Drug Name
SB-743921 Drug Info
Synonyms N-[1-(3-benzyl-7-chloro-4-oxo-quinazolin-2-yl)propyl]-4-bromo-N-(3-dimethylaminopropyl)benzamide
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
49867937
CAS Number
CAS 940929-33-9
TTD Drug ID
DM6XJ9S

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AZD-4877 DMFVL5J Acute myeloid leukaemia 2A60 Phase 2 [3]
ARRY-520 DMTOI7S Multiple myeloma 2A83 Phase 2 [4]
Ispinesib DMP2BWX Head and neck cancer 2D42 Phase 2 [5]
LY2523355 DMCV602 Acute myeloid leukaemia 2A60 Phase 2 [3]
ARQ 621 DMCRLQZ Haematological malignancy 2B33.Y Phase 1 [3]
4SC-205 DMG75P3 Lymphoma 2A80-2A86 Phase 1 [6]
MK-0731 DM2TAUR Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
Monastrol DMLSEJN Discovery agent N.A. Investigative [7]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Kinesin-like protein KIF11 (KIF11) TTTRP0H KIF11_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT00343564) A Study of SB-743921 in Non-Hodgkin's Lymphoma. U.S. National Institutes of Health.
2 Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 Jan-Feb;31(1):47-57.
3 Kinesins and cancer. Nat Rev Cancer. 2012 Jul 24;12(8):527-39.
4 Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells. Leukemia. 2009 Oct;23(10):1755-62.
5 Initial testing (stage 1) of the kinesin spindle protein inhibitor ispinesib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2009 Dec 15;53(7):1255-63.
6 2011 Pipeline of 4SC AG.
7 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.