General Information of Drug (ID: DM6YD3U)

Drug Name
6-fluorotryptophan Drug Info
Synonyms
6-Fluoro-DL-tryptophan; 7730-20-3; 6-fluorotryptophan; 2-amino-3-(6-fluoro-1H-indol-3-yl)propanoic acid; DL-Tryptophan, 6-fluoro-; DL-6-Fluorotryptophane; (+-)-6-Fluorotryptophan; Tryptophan, 6-fluoro-, DL-; NSC 9364; 6-fluoro-D,L-tryptophan; EINECS 231-788-6; BRN 0482552; Tryptophan, 6-fluoro-; ST072163; 2-amino-3-(6-fluoroindol-3-yl)propanoic acid; 6-Fluoro-DL-tryptophan, 97%; D-Tryptophan, 6-fluoro-; 343-92-0; 6-Fluorotryptophan, DL-; ACMC-20mbi4; AC1Q5S5W; SCHEMBL248870; GTPL5126; CHEMBL472222; AC1L3T80; SCHEMBL18029199
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
94937
CAS Number
CAS 7730-20-3
TTD Drug ID
DM6YD3U

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
AGN-2979 DMLQRFO Psychotic disorder 6A20-6A25 Phase 2 [3]
KAR5585 DMXYN1H Pulmonary arterial hypertension BB01.0 Phase 1 [4]
fenclonine DMUBO3E Discovery agent N.A. Investigative [5]
alpha-propyldopacetamide DMQKMX3 Discovery agent N.A. Investigative [5]
Drug Name Drug ID Indication ICD 11 Highest Status REF
fenclonine DMUBO3E Discovery agent N.A. Investigative [6]
alpha-propyldopacetamide DMQKMX3 Discovery agent N.A. Investigative [6]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
L-Tryptophan hydroxylase 2 (TPH2) TT3KLDP TPH2_HUMAN Inhibitor [2]
Tryptophan 5-hydroxylase 1 (TPH1) TTZSJHV TPH1_HUMAN Inhibitor [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5126).
2 (+)-6-fluorotryptophan, an inhibitor of tryptophan hydroxylase: sleep and wakefulness in the rat. Neuropharmacology. 1981 Apr;20(4):335-9.
3 Antidepressant-like action of AGN 2979, a tryptophan hydroxylase activation inhibitor, in a chronic mild stress model of depression in rats. Eur Neuropsychopharmacol. 2001 Oct;11(5):351-7.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1241).
6 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1242).