Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM704HO)

Drug Name
AC-253 Drug Info
Synonyms Antam; Amylin antagonist, Amylin; Amylin antagonist, Glaxo; GG-747
Indication
Disease Entry ICD 11 Status REF
Hypertension BA00-BA04 Discontinued in Phase 1 [1]
Cross-matching ID
TTD Drug ID
DM704HO

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Amylin receptor (IAPPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
DACRA 089 DM5TB76 Type 2 diabetes 5A11 Phase 1 [3]
Davalintide DM9S3R8 Obesity 5B81 Discontinued in Phase 2 [4]
AC-625 DMIJB68 Hypertension BA00-BA04 Discontinued in Phase 1 [2]
AC-187 DM5IDAQ Type-2 diabetes 5A11 Terminated [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Amylin receptor (IAPPR) TTAT87F CALCR_HUMAN-RAMP1_HUMAN/RAMP2_HUMAN/RAMP3_HUMAN Antagonist [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001605)
2 Biotechnology and Its Application in Pharmacy. Kulkarn. 2002. Page157.
3 A novel dual amylin and calcitonin receptor agonist, KBP-089, induces weight loss through a reduction in fat, but not lean mass, while improving food preference. Br J Pharmacol. 2017 Apr;174(7):591-602.
4 Davalintide (AC2307), a novel amylin-mimetic peptide: enhanced pharmacological properties over native amylin to reduce food intake and body weight. Int J Obes (Lond). 2010 Feb;34(2):385-95.
5 Antagonist of the amylin receptor blocks beta-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci. 2004 Jun 16;24(24):5579-84.