Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM72JE4)

Drug Name

FF-10502 Drug Info

Synonyms

UNII-R5B1HX1HUY; R5B1HX1HUY; 184302-49-6; 4-amino-1-((2R,3S,4S,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrothiophen-2-yl)pyrimidin-2(1H)-one; 4'-Thio-fac; SCHEMBL1986004; 4-amino-1-[(2R,3S,4S,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one; 2'beta-Fluoro-4'-O-thia-2'-deoxycytidine; 1-(2-deoxy-2-fluoro-4-thio-beta-d-arabinofuranosyl)cytosine

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 9903330
CAS Number: CAS 184302-49-6
TTD Drug ID: DM72JE4

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
DNA polymerase beta (POLB)	TTA0XPV	DPOLB_HUMAN	Inhibitor	[2]

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References

1	ClinicalTrials.gov (NCT02661542) Study of FF-10502-01 in Patients With Advanced Solid Tumors and Lymphomas. U.S. National Institutes of Health.
2	FF-10502, an Antimetabolite with Novel Activity on Dormant Cells, Is Superior to Gemcitabine for Targeting Pancreatic Cancer Cells. J Pharmacol Exp Ther. 2018 Jul;366(1):125-135.