Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7BWG5)

• Drug Name: 5-BODMT Drug Info
• Synonyms: 5-N-butyryloxy-N,N-dimethyltryptamine; compound 10 [PMID 21422162]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 91827360
  TTD Drug ID: DM7BWG5

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 1F receptor (HTR1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[2]
Lasmiditan	DMXLVDT	Migraine	8A80	Approved	[3]
LY-334370	DM43O9N	Migraine	8A80	Phase 2	[4]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[2]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[5]
1-naphthylpiperazine	DM6BIWK	Discovery agent	N.A.	Investigative	[2]
BRL-15572	DMM61Y2	Discovery agent	N.A.	Investigative	[6]
2-methyl-5-HT	DM1S5CB	N. A.	N. A.	Investigative	[5]
alpha-methyl-5-HT	DMCAYXF	Discovery agent	N.A.	Investigative	[5]
WAY-466	DMMOH51	Discovery agent	N.A.	Investigative	[7]

Drug(s) Targeting 5-HT 1E receptor (HTR1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[8]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[8]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[8]
1-naphthylpiperazine	DM6BIWK	Discovery agent	N.A.	Investigative	[8]
BRL-15572	DMM61Y2	Discovery agent	N.A.	Investigative	[6]
2-methyl-5-HT	DM1S5CB	N. A.	N. A.	Investigative	[5]
alpha-methyl-5-HT	DMCAYXF	Discovery agent	N.A.	Investigative	[8]
m-chlorophenylpiperazine	DMM1J2D	Discovery agent	N.A.	Investigative	[8]
EDMT	DMS3AXK	Discovery agent	N.A.	Investigative	[9]
9-OH-risperidone	DMGORXQ	Discovery agent	N.A.	Investigative	[10]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1E receptor (HTR1E)	TTCPG9S	5HT1E_HUMAN	Agonist	[1]
5-HT 1F receptor (HTR1F)	TT0MI3F	5HT1F_HUMAN	Agonist	[1]

References

• [1] Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7.
• [2] Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76.
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
• [4] Selective seratonin 1F (5-HT(1F)) receptor agonist LY334370 for acute migraine: a randomised controlled trial. Lancet. 2001 Oct 13;358(9289):1230-4.
• [5] Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12.
• [6] SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20.
• [7] Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6.
• [8] Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. Eur J Pharmacol. 2004 Jan 26;484(2-3):127-39.
• [9] 2-Substituted tryptamines: agents with selectivity for 5-HT(6) serotonin receptors. J Med Chem. 2000 Mar 9;43(5):1011-8.
• [10] Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73.