Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7C1AJ)

Drug Name

HT-2157 Drug Info

Synonyms

HT-2157; 303149-14-6; SNAP 37889; UNII-WW4KZW83BX; WW4KZW83BX; HT 2157; CHEMBL210288; SNAP-37889; 1-phenyl-3-[[3-(trifluoromethyl)phenyl]imino]-1h-indol-2-one; 1-phenyl-3-[3-(trifluoromethyl)phenyl]iminoindol-2-one; 1-Phenyl-3-((3-(trifluoromethyl)phenyl)imino)-1H-indol-2-one; SNAP37889; AC1LSUW9; UNII-J4DRJ9BFS1; UNII-EH5R4IAX6Q; J4DRJ9BFS1; EH5R4IAX6Q; Bionet1_002696; SCHEMBL916990; SCHEMBL8273294; GTPL6126; HMS576C18; MolPort-002-854-320; BDBM50187923; ZINC100301780; AKOS005078094; SNAP-37889, (E)-; CS-6094; HT-2157(SNAP37889)

Indication

Disease Entry	ICD 11	Status	REF
Cognitive impairment	6D71	Phase 1/2	[1]

Cross-matching ID

PubChem CID: 1471834
CAS Number: CAS 303149-14-6
TTD Drug ID: DM7C1AJ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Galanin receptor (GAL-R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
galmic	DML9DH8	Discovery agent	N.A.	Investigative	[3]
Sch 202596	DMRC4LE	Discovery agent	N.A.	Investigative	[4]
GalR3ant	DMI7RPT	Discovery agent	N.A.	Investigative	[5]
CYM2503	DM5NFEA	Discovery agent	N.A.	Investigative	[6]
(E)-3-(4-chlorophenylimino)indolin-2-one	DMPOYK2	Discovery agent	N.A.	Investigative	[7]
SNAP 398299	DMS1AFL	Discovery agent	N.A.	Investigative	[2]
(E)-3-(2,3-dichlorophenylimino)indolin-2-one	DM1LG27	Discovery agent	N.A.	Investigative	[7]
2,3-dihydro-1,4-dithiin-1,1,4,4-tetroxide	DMJB7W1	Discovery agent	N.A.	Investigative	[8]
dithiipin-1,1,4,4-tetroxide analogue 7	DMK0VFS	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Galanin receptor (GAL-R)	TTOPAY7	GALR1_HUMAN; GALR2_HUMAN; GALR3_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6126).
2	Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94.
3	Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10470-5.
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 245).
5	Galanin (2-11) binds to GalR3 in transfected cell lines: limitations for pharmacological definition of receptor subtypes. Neuropeptides. 2005 Jun;39(3):165-7.
6	GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models. Proc Natl Acad Sci U S A. 2010 Aug 24;107(34):15229-34.
7	3-arylimino-2-indolones are potent and selective galanin GAL3 receptor antagonists. J Med Chem. 2006 Jun 29;49(13):3757-8.
8	2,3-Dihydro-dithiin and -dithiepine-1,1,4,4-tetroxides: small molecule non-peptide antagonists of the human galanin hGAL-1 receptor. Bioorg Med Chem. 2000 Jun;8(6):1383-91.