Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7I6VO)

Drug Name

SC-241 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Anxiety disorder	6B00-6B0Z	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Corticotropin-releasing factor receptor 2 (CRHR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Urocortin 2	DM0YO4Q	Congestive heart failure	BD10	Phase 2	[3]
RT-400	DM8DVC9	Acute decompensated heart failure	BD1Z	Phase 2	[4]
NBI-34041	DM5BQK3	Eating disorder	6B82	Phase 1	[5]
PF-572778	DMZ8HW7	Generalized anxiety disorder	6B00	Terminated	[6]
astressin	DMSFLTK	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticotropin-releasing factor receptor 2 (CRHR2)	TTIY658	CRFR2_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008644)
2	US patent application no. 2015,0094,310, Crhr1 antagonists for use in the treatment of patients having crh overactivity.
3	Evolution of complementary peptide systems: teneurin C-terminal-associated peptides and corticotropin-releasing factor superfamilies. Ann N Y Acad Sci. 2009 Apr;1163:215-20.
4	Advances in therapeutic peptides targeting G protein-coupled receptors. Nat Rev Drug Discov. 2020 Jun;19(6):389-413.
5	Emerging drugs for eating disorder treatment. Expert Opin Emerg Drugs. 2006 May;11(2):315-36.
6	WO patent application no. 2013,1603,15, Genetic predictors of response to treatment with crhr1 antagonists.
7	Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors. J Pharmacol Exp Ther. 1999 Feb;288(2):729-34.