Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7IFNB)

• Drug Name: LY3202626 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 78210254
  TTD Drug ID: DM7IFNB

Molecule-Related Drug Atlas

Drug(s) Targeting Beta-secretase (BACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(S)-FLURBIPROFEN	DMF2O4T	Myalgia	FB56.2	Preregistration	[2]
E-2609	DMTNUJ8	Alzheimer disease	8A20	Phase 3	[3]
verubecestat	DM4CGH5	Alzheimer disease	8A20	Phase 3	[4]
Lanabecestat	DMFJLB6	Alzheimer disease	8A20	Phase 3	[1]
AZD3293	DMJQHXD	Alzheimer disease	8A20	Phase 2/3	[5]
JNJ-54861911	DMGPJ5U	Alzheimer disease	8A20	Phase 2/3	[1]
R-flurbiprofen	DMFIVSR	N. A.	N. A.	Phase 2	[2]
LY2886721	DMV14LM	Alzheimer disease	8A20	Phase 2	[6]
AZD-3839	DM72FOD	Alzheimer disease	8A20	Phase 1	[7]
LY-2811376	DM8LGWR	Alzheimer disease	8A20	Phase 1	[8]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Beta-secretase (BACE)	TT8JRS7	NOUNIPROTAC	Inhibitor	[1]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2219-23.
• [3] Targeting the beta secretase BACE1 for Alzheimer's disease therapy. Lancet Neurol. 2014 March; 13(3): 319-329.
• [4] BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimers Res Ther. 2014 Dec 24;6(9):89.
• [5] AZD3293 A novel BACE1 inhibitor: safety, tolerability, and effects on plasma and CSF A-beta peptides following single- and multiple-dose administration. Neurobiology of Aging. May 20, 2008.
• [6] Lessons from a BACE1 inhibitor trial: off-site but not off base.Alzheimers Dement.2014 Oct;10(5 Suppl):S411-9.
• [7] Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease. J Biol Chem. 2012 Nov 30;287(49):41245-57.
• [8] Neurodegenerative disease: Inhibiting beta-secretase in humans. Nature Reviews Drug Discovery 11, 21 (January 2012).