Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7J41B)

Drug Name

GSK3772847 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

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Drug(s) Targeting Interleukin-1 receptor-like 1 (IL1RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Astegolimab	DMKOHC5	Chronic obstructive pulmonary disease	CA22	Phase 3	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-1 receptor-like 1 (IL1RL1)	TT4GZA4	ILRL1_HUMAN	Not Available	[2]

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References

1	ClinicalTrials.gov (NCT03207243) A Randomized, Double-blind, Parallel Group, Multicenter, Stratified Study Evaluating the Efficacy and Safety of Repeat Doses of GSK3772847 Compared With Placebo in Participants With Moderately Severe Asthma. U.S.National Institutes of Health.
2	Efficacy and safety of GSK3772847 in participants with moderate-to-severe asthma with allergic fungal airway disease: A phase IIa randomized, multicenter, double-blind, sponsor-open, comparative trial. PLoS One. 2023 Feb 3;18(2):e0281205.
3	Astegolimab, an anti-ST2, in chronic obstructive pulmonary disease (COPD-ST2OP): a phase 2a, placebo-controlled trial. Lancet Respir Med. 2022 May;10(5):469-477.