Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7K19L)

Drug Name

ISIS 2974 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting ICAM1 messenger RNA (ICAM1 mRNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ISIS 1570	DMJ9G23	Lleum inflammation	1A40.0	Approved	[1]
Alicaforsen	DMQ509J	Lleum inflammation	1A40.0	Phase 3	[2]
INXC-ICAM1	DMODQW0	Transplant rejection	NE84	Terminated	[3]
A-286982	DM98VFW	Discovery agent	N.A.	Investigative	[4]
ISIS 11159	DM9V6FW	Discovery agent	N.A.	Investigative	[5]
ISIS 3224	DMAFEYG	Discovery agent	N.A.	Investigative	[5]
ISIS 1931	DMBMQNI	Discovery agent	N.A.	Investigative	[1]
PIPERROLEIN B	DMRVHWZ	Discovery agent	N.A.	Investigative	[6]
Dehydropipernonaline	DMIOA9M	Discovery agent	N.A.	Investigative	[6]
ISIS 3067	DMC9OL7	Discovery agent	N.A.	Investigative	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	US patent application no. 6,300,491, Oligonucleotide inhibition of cell adhesion.
2	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
3	ISIS 2302. INXC ICAM1, Oligo-TCS. Drugs R D. 1999 Jan;1(1):85-6.
4	Discovery of tetrahydroisoquinoline (THIQ) derivatives as potent and orally bioavailable LFA-1/ICAM-1 antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5269-73.
5	US patent application no. 5,789,573, Antisense inhibition of ICAM-1, E-selectin, and CMV IE1/IE2.
6	Alkamides from the fruits of Piper longum and Piper nigrum displaying potent cell adhesion inhibition. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4544-6.