Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7K4YR)

• Drug Name: MIS-416 Drug Info
• Synonyms: Microparticle adjuvant (anthrax), Virionyx; Microparticle adjuvant (iv, autoimmune disease/cancer/anthrax), Innate Therapeutics

Indication

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Phase 2	[1]
Bacillus anthracis infection	1G40	Investigative	[1]

• Cross-matching ID: TTD Drug ID: DM7K4YR

Molecule-Related Drug Atlas

Drug(s) Targeting Toll-like receptor 9 (TLR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cadi-05	DMPTCYB	Prostate cancer	2C82.0	Phase 3	[3]
SD-101	DMAMTGI	Hepatitis C virus infection	1E51.1	Phase 3	[4]
MGN-1703	DMCJRL1	Colorectal cancer	2B91.Z	Phase 3	[5]
IMO-2125	DM735FA	Melanoma	2C30	Phase 3	[6]
Tilsotolimod	DMGYK2N	Melanoma	2C30	Phase 3	[7]
IMO-3100	DMM549D	Psoriasis vulgaris	EA90	Phase 2	[8]
BL-7040	DMSBPJI	Inflammatory bowel disease	DD72	Phase 2	[9]
CYT003	DM4LJH8	Asthma	CA23	Phase 2	[10]
CpG-10101	DM6MUCX	Hepatitis C virus infection	1E51.1	Phase 2	[11]
JVRS-100	DMPMU38	leukaemia	2A60-2B33	Phase 2	[12]

Drug(s) Targeting Pattern recognition receptor NOD2 (NOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SB-9200	DMJRK6D	Hepatitis B virus infection	1E51.0	Phase 2	[13]
muramyl dipeptide	DM4FR71	Discovery agent	N.A.	Investigative	[14]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Pattern recognition receptor NOD2 (NOD2)	TTYPUHA	NOD2_HUMAN	Modulator	[2]
Toll-like receptor 9 (TLR9)	TTSHG0T	TLR9_HUMAN	Modulator	[2]

References

• [1] Targeting Innate Receptors with MIS416 Reshapes Th Responses and Suppresses CNS Disease in a Mouse Model of Multiple Sclerosis. PLoS ONE 9(1): e87712. January 31, 2014.
• [2] DOI: 10.1371/journal.pone.0087712
• [3] Trial Watch: Experimental Toll-like receptor agonists for cancer therapy. Oncoimmunology. 2012 August 1; 1(5): 699-716.
• [4] Novel drugs targeting Toll-like receptors for antiviral therapy. Future Virol. 2014 September; 9(9): 811-829.
• [5] Maintenance treatment with the immunomodulator MGN1703, a Toll-like receptor 9 (TLR9) agonist, in patients with metastatic colorectal carcinoma and disease control after chemotherapy: a randomised, double-blind, placebo-controlled trial. J Cancer Res Clin Oncol. 2014 Sep;140(9):1615-24.
• [6] Clinical pipeline report, company report or official report of Idera Pharmaceuticals (2011).
• [7] Tilsotolimod with ipilimumab drives tumor responses in anti-PD-1 refractory melanoma. Cancer Discov. 2021 Mar 11;candisc.1546.2020.
• [8] Company report (Iderapharma)
• [9] Gut feeling: MicroRNA discriminators of the intestinal TLR9-cholinergic links. Int Immunopharmacol. 2015 Nov;29(1):8-14.
• [10] CYT003, a TLR9 agonist, in persistent allergic asthma - a randomized placebo-controlled Phase 2b study. Allergy. 2015 Sep;70(9):1160-8.
• [11] Safety, pharmacokinetics and immune effects in normal volunteers of CPG 10101 (ACTILON), an investigational synthetic toll-like receptor 9 agonist. Antivir Ther. 2007;12(5):741-51.
• [12] Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone ) increases antibody response, cellular immunity, and antigenically drifted protection. Vaccine. 2009 June 12; 27(29):3811-3820.
• [13] Company reprot (Spring Bank Pharmaceuticals) (drug: SB 9200)
• [14] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1763).