Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7M5VY)

Drug Name

NITROCEFIN Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Bacterial DD-carboxypeptidase (Bact vanYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefalotin	DMVYSLE	Bacteremia	1A73	Approved	[2]
B-Lactams	DMR8YD6	Bacterial infection	1A00-1C4Z	Approved	[3]
Cephalosporin	DM79XDW	Bacterial infection	1A00-1C4Z	Approved	[4]
Cefotaxime	DMEB837	Bacteremia	1A73	Approved	[5]
TD-1792	DMGKBZH	Skin infection	1F28-1G0Z	Phase 3	[6]
Phenyl Boronic acid	DMFZH49	Discovery agent	N.A.	Investigative	[7]
Cephalosporin C	DMYW3ZG	Discovery agent	N.A.	Investigative	[8]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[9]
D-Alanine	DMVIDQL	Discovery agent	N.A.	Investigative	[9]
3-boronobenzoic acid	DMRCJW0	Discovery agent	N.A.	Investigative	[7]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial DD-carboxypeptidase (Bact vanYB)	TTLP6GN	VANY_ENTFA	Inhibitor	[1]

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References

1	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
2	Binding of cephalothin and cefotaxime to D-ala-D-ala-peptidase reveals a functional basis of a natural mutation in a low-affinity penicillin-binding protein and in extended-spectrum beta-lactamases. Biochemistry. 1995 Jul 25;34(29):9532-40.
3	Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
4	A 1.2-A snapshot of the final step of bacterial cell wall biosynthesis. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1427-31.
5	Extended-spectrum cephalosporinases: structure, detection and epidemiology. Future Microbiol. 2007 Jun;2:297-307.
6	How many modes of action should an antibiotic have Curr Opin Pharmacol. 2008 Oct;8(5):564-73.
7	Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as D,D-carboxypeptidase R39 inhibitors. J Med Chem. 2009 Oct 8;52(19):6097-106.
8	DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
9	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.