Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7MDZE)

Drug Name

SR1078 Drug Info

Synonyms

1246525-60-9; SR 1078; SR-1078; N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-4-(trifluoromethyl)benzamide; CHEMBL3094387; N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-4-(trifluoromethyl)benzamide; N-[4-[2,2,2-Trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-4-(trifluoromethyl)benzamide; SCHEMBL4880524; C17H10F9NO2; DTXSID30591895; BCP09203; EX-A2215; 4063AH; BDBM50444350; s5775; ZINC98052696; AKOS024458390; CS-1045; NCGC00379222-02; AK547149; AS-55921; HY-14422; W-5797; SR-03000001078; SR-03000001078-1; SR-03000001078-2

Indication

Disease Entry	ICD 11	Status	REF
Liver cancer	2C12	Preclinical	[1]

Cross-matching ID

PubChem CID: 17980288
CAS Number: CAS 1246525-60-9
TTD Drug ID: DM7MDZE

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Nuclear receptor ROR-gamma (RORG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK2981278	DM25YLM	Plaque psoriasis	EA90.0	Phase 2	[3]
LYC-55716	DMV8WU9	Non-small-cell lung cancer	2C25.Y	Phase 2	[4]
VTP-43742	DMCA8G1	Psoriasis vulgaris	EA90	Phase 2	[3]
ESR0114	DMUNM4D	Plaque psoriasis	EA90.0	Phase 1/2	[5]
AZD0284	DMHBEKM	Plaque psoriasis	EA90.0	Phase 1	[5]
ARN-6039	DM4D85V	Multiple sclerosis	8A40	Phase 1	[6]
TAK-828	DMW43DL	Crohn disease	DD70	Phase 1	[3]
BBI-6000	DMTG9WM	Psoriasis vulgaris	EA90	Phase 1	[5]
JNJ-3534	DM49VWQ	Psoriasis vulgaris	EA90	Phase 1	[5]
JTE-451	DM01JU8	Plaque psoriasis	EA90.0	Phase 1	[5]
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⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Nuclear receptor ROR-alpha (RORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9598431, 3	DMRC4O7	N. A.	N. A.	Patented	[7]
SR3335	DM96IUW	Type-2 diabetes	5A11	Preclinical	[8]
7-hydroxycholesterol	DMZXMB7	Discovery agent	N.A.	Investigative	[9]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear receptor ROR-alpha (RORA)	TT1TYN7	RORA_HUMAN	Agonist	[2]
Nuclear receptor ROR-gamma (RORG)	TTGV6LY	RORG_HUMAN	Agonist	[2]

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References

1	Circadian rhythm as a therapeutic target. Nat Rev Drug Discov. 2021 Apr;20(4):287-307.
2	Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORalpha and ROR. ACS Chem Biol. 2010 Nov 19;5(11):1029-34.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7	Compounds useful for inhibiting ROR-gamma-t. US9598431.
8	Identification of SR3335 (ML-176): a synthetic RORalpha selective inverse agonist. ACS Chem Biol. 2011 Mar 18;6(3):218-22.
9	Identification of natural ligands of retinoic acid receptor-related orphan receptor alpha ligand-binding domain expressed in Sf9 cells--a mass spectrometry approach. Anal Biochem. 2003 Dec 1;323(1):139-49.