Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7MSGK)

Drug Name

SM 21 Drug Info

Synonyms

SM-21; (RS)-SM21; (+/-)-SM21

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MIN-101	DMCJY35	Schizophrenia	6A20	Phase 3	[3]
CT1812	DMBRKZ7	Alzheimer disease	8A20	Phase 2	[4]
Isoindoline derivative 5	DMIUTQW	N. A.	N. A.	Patented	[5]
Isoindoline derivative 3	DM2MYL9	N. A.	N. A.	Patented	[5]
Isoindoline derivative 4	DMP1NKI	N. A.	N. A.	Patented	[5]
Isoindoline derivative 2	DMTE0S3	N. A.	N. A.	Patented	[5]
Isoindoline derivative 1	DMD19QC	N. A.	N. A.	Patented	[5]
Benzamide derivative 9	DMVFSJZ	N. A.	N. A.	Patented	[5]
Benzamide derivative 10	DM9PKU2	N. A.	N. A.	Patented	[5]
PMID30185082-Compound-57	DMNDF1Z	N. A.	N. A.	Patented	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Sigma intracellular receptor 2 (TMEM97)	TT9NXW4	SGMR2_HUMAN	Antagonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6682).
2	The analgesic tropane analogue (+/-)-SM 21 has a high affinity for sigma2 receptors. Life Sci. 1999;64(10):PL131-7.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	The sigma-2 (-2) receptor: a review of recent patent applications: 2013-2018.Expert Opin Ther Pat. 2018 Sep;28(9):655-663.