Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7OTQS)

Drug Name

JNJ-10311795 Drug Info

Synonyms

JNJ-10311795; CHEMBL374027; 518062-14-1; SCHEMBL1260969; GTPL6563; BDBM50208224; Phosphonic acid, (2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naphthalenyl)-2-oxoethyl)-; Phosphonic acid, P-(2-(3-((methyl(1-(2-naphthalenylcarbonyl)-4-piperidinyl)amino)carbonyl)-2-naphthalenyl)-1-(1-naphthalenyl)-2-oxoethyl)-; [2-[3-[methyl-[1-(naphthalene-2-carbonyl)piperidin-4-yl]carbamoyl]naphthalen-2-yl]-1-naphthalen-1-yl-2-oxoethyl]phosphonic acid

Indication

Disease Entry	ICD 11	Status	REF
Chronic obstructive pulmonary disease	CA22	Phase 2	[1]

Cross-matching ID

PubChem CID: 10146470
CAS Number: CAS 518062-14-1
TTD Drug ID: DM7OTQS

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Patented Agent(s)

Discontinued Drug(s)

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Drug(s) Targeting Chymase (CYM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SUN13834	DMPK34E	Gram-positive bacterial infection	1B74-1G40	Phase 2	[3]
ASB17061	DMNVU28	Atopic dermatitis	EA80	Phase 2	[4]
BAY 11-42524	DM8SNEM	Left ventricular dysfunction	BD11	Phase 2	[5]
BAY 1142524	DMHKTGX	Myocardial infarction	BA41-BA43	Phase 2	[6]
2-(N-Morpholino)-Ethanesulfonic Acid	DMZVHSB	Discovery agent	N.A.	Investigative	[7]
Benzylsulfinic Acid	DM7XK28	Discovery agent	N.A.	Investigative	[8]
KM-01221	DMG594K	Cardiovascular disease	BA00-BE2Z	Investigative	[9]
Y-40613	DM412IV	Discovery agent	N.A.	Investigative	[10]
Rac-2q	DMD5TPH	Discovery agent	N.A.	Investigative	[11]
Phenylalanylmethane	DMZNFT2	Discovery agent	N.A.	Investigative	[7]
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Drug(s) Targeting Cathepsin G (CTSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Peptide analog 59	DMZAMNX	N. A.	N. A.	Patented	[12]
Peptide analog 61	DM45JMT	N. A.	N. A.	Patented	[12]
Peptide analog 55	DMVLP8H	N. A.	N. A.	Patented	[12]
Peptide analog 60	DMMSTNA	N. A.	N. A.	Patented	[12]
Peptide analog 70	DMN43Q5	N. A.	N. A.	Patented	[12]
Peptide analog 56	DMBCFJU	N. A.	N. A.	Patented	[12]
Peptide analog 57	DM6IQWE	N. A.	N. A.	Patented	[12]
Peptide analog 58	DM7X62M	N. A.	N. A.	Patented	[12]
Peptide analog 62	DM28NK0	N. A.	N. A.	Patented	[12]
Aloxistatin	DMGW07M	Neurological disorder	6B60	Discontinued in Phase 3	[13]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cathepsin G (CTSG)	TTQAJF1	CATG_HUMAN	Inhibitor	[2]
Chymase (CYM)	TT8VUE0	CMA1_HUMAN	Inhibitor	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6563).
2	Discovery of potent, selective, orally active, nonpeptide inhibitors of human mast cell chymase. J Med Chem. 2007 Apr 19;50(8):1727-30.
3	Oral chymase inhibitor SUN13834 ameliorates skin inflammation as well as pruritus in mouse model for atopic dermatitis.Eur J Pharmacol.2008 Dec 28;601(1-3):186-91.
4	Immunology of atopic eczema: overcoming the Th1/Th2 paradigm. Allergy. 2013 Aug;68(8):974-82.
5	ClinicalTrials.gov (NCT02452515) A Single-blind Pilot Study to Investigate Safety and Tolerability of the Chymase Inhibitor BAY1142524 in Clinically Stable Patients With Left-ventricular Dysfunction.
6	Pharmacokinetics, Safety, and Tolerability of the Novel Chymase Inhibitor BAY 1142524 in Healthy Male Volunteers. Clin Pharmacol Drug Dev. 2019 May;8(4):467-479.
7	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
8	The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
9	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2340).
10	Therapeutic potential of a specific chymase inhibitor in atopic dermatitis. Jpn J Pharmacol. 2002 Nov;90(3):214-7.
11	Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4.
12	Neutrophil elastase inhibitors: a patent review and potential applications for inflammatory lung diseases (2010 - 2014).Expert Opin Ther Pat. 2015;25(10):1145-58.
13	Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem. 2007 Jul 20;282(29):20836-46.