Details of the Drug-Related molecule(s) Interaction Atlas

BDBM50363773 Drug Info

CHEMBL1945137; CHEMBL1962885; BDBM50363773

Cross-matching ID

PubChem CID

49847196

TTD Drug ID

DM7TASJ

General Information of Drug (ID: DM7TASJ)

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Patented Agent(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting NAD-dependent deacetylase sirtuin-2 (SIRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BDBM50363780	DM46UPM	N. A.	N. A.	Patented	[1]
BDBM50363782	DMUQI15	N. A.	N. A.	Patented	[1]
AC1LFGWU	DMXI3O0	N. A.	N. A.	Patented	[2]
ZINC915379	DMW9P6U	N. A.	N. A.	Patented	[2]
US9359293, TM	DM0NIB5	N. A.	N. A.	Patented	[3]
US9359293, TA	DMA3OI4	N. A.	N. A.	Patented	[3]
US9359293, TB	DMRQ2G4	N. A.	N. A.	Patented	[3]
AC1LOJYQ	DMVX9NK	N. A.	N. A.	Patented	[2]
AGK2	DM26AMU	Discovery agent	N.A.	Investigative	[4]
INDUS-815C	DMLJ645	Retinopathy	9B71	Investigative	[5]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
NAD-dependent deacetylase sirtuin-2 (SIRT2)	TTLKF5M	SIR2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Aroyl thiourea derivatives. US9365508.
2	Small molecule activators of NRF2 pathway. US9737525.
3	Methods of treatment using modulators of SIRT2. US9359293.
4	Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007 Jul 27;317(5837):516-9.
5	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2708).