Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7VCDZ)

Drug Name

WY-47766 Drug Info

Synonyms

OST-766

Indication

Disease Entry	ICD 11	Status	REF
Osteoporosis	FB83.0	Discontinued in Phase 2	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Vacuolar-type proton ATPase (v-ATPase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SB 242784	DMFXJDL	Arterial calcification	BD52.Y	Preclinical	[3]
Salicylihalamide A	DMGXVRZ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[4]
FR167356	DMF53Z7	Osteoporosis	FB83.0	Preclinical	[5]
Lobatamide A	DM2GBEW	Discovery agent	N.A.	Investigative	[4]
Lobatamide C	DMFIDJS	Discovery agent	N.A.	Investigative	[4]
Oximidine II	DMW6K80	Discovery agent	N.A.	Investigative	[4]
Lobatamide D	DMG706J	Discovery agent	N.A.	Investigative	[4]
Lobatamide B	DMD91RI	Discovery agent	N.A.	Investigative	[4]
Oximidine I	DMG6O0L	Discovery agent	N.A.	Investigative	[4]
Lobatamide F	DM6BWGQ	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vacuolar-type proton ATPase (v-ATPase)	TTTK3BH	NOUNIPROTAC	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003235)
2	A pharmacological assessment of the mammalian osteoclast vacuolar H(+)-ATPase. Bone Miner. 1994 Nov;27(2):159-66.
3	SB 242784, a selective inhibitor of the osteoclastic V-H+ATPase, inhibits arterial calcification in the rat. Circ Res. 2002 Sep 20;91(6):547-52.
4	Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. J Pharmacol Exp Ther. 2001 Apr;297(1):114-20.
5	Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.