Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7XES6)

Drug Name

ANX-042 Drug Info

Synonyms

BNP sliced variant (heart failure), Anexon; B-type natriuretic peptide spliced variant (heart failure), Anexon

Indication

Disease Entry	ICD 11	Status	REF
Chronic heart failure	BD1Z	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Natriuretic peptide receptor (NPR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AP811	DMILA4P	Discovery agent	N.A.	Investigative	[3]
M372049	DMYU3Z7	Discovery agent	N.A.	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Natriuretic peptide receptor (NPR3)	TTWVLS6	ANPRC_HUMAN	Modulator	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800036485)
2	Renin-Angiotensin Blockade Combined With Natriuretic Peptide System Augmentation: Novel Therapeutic Concepts to Combat Heart Failure. Circ Heart Fail. 2013 May; 6(3): 594-605.
3	The discovery of non-basic atrial natriuretic peptide clearance receptor antagonists. Part 1. Bioorg Med Chem Lett. 2000 Sep 4;10(17):1949-52.
4	Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for e... Circulation. 2004 Sep 7;110(10):1231-5.