Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7Y1SO)

Drug Name

UNC0642 Drug Info

Synonyms

1481677-78-4; UNC 0642; UNC-0642; CHEMBL2441082; 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine; Barrett; GTPL7017; SCHEMBL17372593; AOB2595; MolPort-035-765-953; EX-A2241; BCP08266; ZINC96285772; BDBM50442103; AKOS024458509; SB19046; CS-5269; NCGC00189140-01; NCGC00189140-02; AS-16721; HY-13980; BC600721; AK547424; UNC0642, > KB-146019; J-008448

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 53315878
TTD Drug ID: DM7Y1SO

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Investigative Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Euchromatic histone-lysine N-methyltransferase 1 (EHMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIX-01294	DM5CBNY	Breast cancer	2C60-2C65	Preclinical	[2]
A-366	DM1H45U	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
UNC0638	DM4A1KJ	Discovery agent	N.A.	Investigative	[4]
------------------------------------------------------------------------------------

Drug(s) Targeting Histone-lysine N-methyltransferase EHMT2 (EHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIX-01294	DM5CBNY	Breast cancer	2C60-2C65	Preclinical	[2]
A-366	DM1H45U	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
MS012	DM5AMFV	Inflammation	1A00-CA43.1	Preclinical	[5]
UNC0638	DM4A1KJ	Discovery agent	N.A.	Investigative	[4]
UNC0321	DMCVU1T	Discovery agent	N.A.	Investigative	[6]
BRD9539	DMFAVB5	Discovery agent	N.A.	Investigative	[7]
------------------------------------------------------------------------------------


⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Euchromatic histone-lysine N-methyltransferase 1 (EHMT1)	TTOFXD7	EHMT1_HUMAN	Inhibitor	[1]
Histone-lysine N-methyltransferase EHMT2 (EHMT2)	TTS6RZT	EHMT2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP. J Med Chem. 2013 Nov 14;56(21):8931-42.
2	Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Mol Cell. 2007 Feb 9;25(3):473-81.
3	Discovery and development of potent and selective inhibitors of histone methyltransferase g9a. ACS Med Chem Lett. 2014 Jan 2;5(2):205-9.
4	A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol. 2011 Jul 10;7(8):566-74.
5	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
6	Protein lysine methyltransferase G9a inhibitors: design, synthesis, and structure activity relationships of 2,4-diamino-7-aminoalkoxy-quinazolines. J Med Chem. 2010 Aug 12;53(15):5844-57.
7	A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma. ACS Chem Biol. 2012 Jul 20;7(7):1152-7.