General Information of Drug (ID: DM7YII9)

Drug Name
Dazodalibep Drug Info
Synonyms VIB4920
Indication
Disease Entry ICD 11 Status REF
Kidney transplant rejection NE84 Phase 2 [1]
Rheumatoid arthritis FA20 Phase 2 [2]
Sjogren syndrome 4A43.20 Phase 2 [3]
Cross-matching ID
TTD Drug ID
DM7YII9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Drug(s) Targeting CD40L receptor (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BI 655064 DMF86P2 Lupus 4A40 Phase 2 [5]
APX005M DMX2P5G Melanoma 2C30 Phase 2 [6]
ASKP-1240 DM1CLKO Transplant rejection NE84 Phase 2 [7]
CFZ533 DM1TWIE Graves disease 5A02.0 Phase 2 [5]
Iscalimab DMW4CR8 Type-1 diabetes 5A10 Phase 2 [8]
KPL-404 DMQJODL Rheumatoid arthritis FA20 Phase 2 [9]
AT-1501 DMQIA5K Amyotrophic lateral sclerosis 8B60.0 Phase 2 [10]
Frexalimab DMMJTYP Multiple sclerosis 8A40 Phase 2 [11]
SL-172154 DMN3D72 Ovarian cancer 2C73 Phase 1 [12]
GEN1042 DMNP6T3 Solid tumour/cancer 2A00-2F9Z Phase 1 [13]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CD40L receptor (CD40) TTN6Y9A TNR5_HUMAN Inhibitor [4]

References

1 ClinicalTrials.gov (NCT04046549) A Phase 2a Single-arm, Prospective, Open-label Pilot Study to Evaluate the Safety and Efficacy of Dual Costimulation Blockade With VIB4920 and Belatacept for Prophylaxis of Allograft Rejection in Adults Receiving a Kidney Transplant. U.S.National Institutes of Health.
2 ClinicalTrials.gov (NCT04163991) A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Mechanistic Insight and Dosage Optimization Study of the Efficacy and Safety of VIB4920 in Patients With Rheumatoid Arthritis (RA). U.S.National Institutes of Health.
3 ClinicalTrials.gov (NCT04129164) A Phase 2 Randomized, Double-blind, Placebo-controlled, Proof of Concept Study to Evaluate the Efficacy and Safety of VIB4920 in Subjects With Sj?gren's Syndrome (SS). U.S.National Institutes of Health.
4 The enhanced immunopharmacology of VIB4920, a novel Tn3 fusion protein and CD40L antagonist, and assessment of its safety profile in cynomolgus monkeys. Br J Pharmacol. 2020 Mar;177(5):1061-1076.
5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1874).
8 Developments in immunosuppression. Curr Opin Organ Transplant. 2021 Feb 1;26(1):91-96.
9 Anti-CD40 antibody KPL-404 inhibits T cell-mediated activation of B cells from healthy donors and autoimmune patients. Arthritis Res Ther. 2021 Jan 6;23(1):5.
10 ClinicalTrials.gov (NCT04322149) A Phase 2a Open-Label, Multi-Center Study to Evaluate the Safety and Tolerability of Multiple Doses of AT-1501 in Adults With ALS. U.S.National Institutes of Health.
11 ClinicalTrials.gov (NCT04879628) A Phase 2, Double-blind, Randomized, Placebo-controlled Study Assessing Efficacy and Safety of SAR441344, a CD40L-antagonist Monoclonal Antibody, in Participants With Relapsing Multiple Sclerosis. U.S.National Institutes of Health.
12 Clinical pipeline report, company report or official report of Shattuck Labs.
13 Clinical pipeline report, company report or official report of Genmab.