Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM80HOV)

Drug Name

SDF-1 Drug Info

Synonyms

JVS-100

Indication

Disease Entry	ICD 11	Status	REF
Heart failure	BD10-BD13	Phase 2	[1]
Peripheral arterial disease	BD4Z	Phase 2	[2]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dociparstat sodium	DMQLSMB	Acute myeloid leukaemia	2A60	Phase 3	[4]
MyoCell SDF-1	DMS9GE1	Heart failure	BD10-BD13	Phase 3	[5]
NOX-A12	DMMKN4Q	Macular degeneration	9B78.3	Phase 1	[6]
REC-02	DMHT5XV	Congestive heart failure	BD10	Phase 1	[2]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Stromal cell-derived factor 1 (CXCL12)	TT4UGTF	SDF1_HUMAN	Inhibitor	[3]

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References

1	ClinicalTrials.gov (NCT01643590) Study to Evaluate the Safety and Efficacy of JVS-100 Administered to Adults With Ischemic Heart Failure.. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	SDF-1 in myocardial repair. Gene Ther. 2012 Jun;19(6):583-7.
4	Clinical pipeline report, company report or official report of Chimerix.
5	Stromal cell-derived factor-1 (SDF-1): homing factor for engineered regenerative medicine. Expert Opin Biol Ther. 2011 Feb;11(2):189-97.
6	SDF-1/CXCR4/CXCR7 is pivotal for vascular smooth muscle cell proliferation and chronic allograft vasculopathy. Transpl Int. 2015 Dec;28(12):1426-35.