Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM81D4I)

• Drug Name: PF-4447943 Drug Info
• Synonyms: BCP16255

Indication

Disease Entry	ICD 11	Status	REF
Alzheimer disease	8A20	Phase 2	[1]
Sickle-cell disorder	3A51	Phase 1	[2]

• Cross-matching ID:
  PubChem CID: 135564558
  CAS Number: CAS 1082744-20-4
  TTD Drug ID: DM81D4I

Molecule-Related Drug Atlas

Drug(s) Targeting Phosphodiesterase 9 (PDE9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ASP-4901	DMZUAH2	Genitourinary disease	GA0Z-GC8Z	Phase 2	[4]
E2027	DMK8SY6	Lewy body dementia	6D82	Phase 2	[5]
BI-409306	DMJFDS0	Alzheimer disease	8A20	Phase 2	[6]
IMR-687	DM15MRZ	Sickle-cell disorder	3A51	Phase 2	[7]
CRD-740	DMRTX0K	Heart failure	BD10-BD13	Phase 2	[8]
TT-00920	DMP6G0P	Heart failure	BD10-BD13	Phase 1	[9]
SCH51866	DMCWSJP	Discovery agent	N.A.	Investigative	[10]
PF-4181366	DMC8G4S	Cognitive impairment	6D71	Investigative	[11]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 9 (PDE9)	TTZOEBC	PDE9A_HUMAN	Inhibitor	[3]

References

• [1] ClinicalTrials.gov (NCT00930059) A Study Of PF-04447943 Compared To Placebo In Subjects With Mild To Moderate Alzheimer's Disease. U.S. National Institutes of Health.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] A multicenter, double-blind, placebo-controlled trial of the PDE9A inhibitor, PF-04447943, in Alzheimer's disease. Curr Alzheimer Res. 2014;11(5):413-21.
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033070)
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] Clinical pipeline report, company report or official report of Boehringer Ingelheim pipeline.
• [7] Clinical pipeline report, company report or official report of Imara.
• [8] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [9] Clinical pipeline report, company report or official report of TransThera Biosciences
• [10] Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem. 1998 Jun 19;273(25):15559-64.
• [11] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1309).