Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM83THZ)

Drug Name

RQ-00203078 Drug Info

Synonyms

TRPM8 antagonists (pain), RaQualia Pharma

Indication

Disease Entry	ICD 11	Status	REF
Neuropathic pain	8E43.0	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Long transient receptor potential channel 8 (TRPM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[2]
D-3263	DM7V2OM	Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]
PF-05105679	DM4QPT0	Pain	MG30-MG3Z	Phase 1	[4]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[5]
ACAA	DMACYPW	Discovery agent	N.A.	Investigative	[1]
5-METHOXYTRYPTAMINE	DMARCKD	Discovery agent	N.A.	Investigative	[6]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[7]
2-(5-fluoro-1H-indol-3-yl)ethanamine	DMHW5FT	Discovery agent	N.A.	Investigative	[6]
NADA	DM3ORGM	Discovery agent	N.A.	Investigative	[1]
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine	DMD2QVO	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Antagonist	[1]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 500).
2	TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
3	Best of the 2009 AUA Annual Meeting: Highlights from the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL. Rev Urol. 2009 Spring; 11(2): 82-107.
4	Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69.
5	Effects of antagonists and heat on TRPM8 channel currents in dorsal root ganglion neuron activated by nociceptive cold stress and menthol. Neurochem Res. 2012 Feb;37(2):314-20.
6	5-benzyloxytryptamine as an antagonist of TRPM8. Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9.
7	Evolution of thermal response properties in a cold-activated TRP channel. PLoS One. 2009 May 29;4(5):e5741.