Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM84GAQ)

Drug Name
20-hydroxy-LTB4 Drug Info
Synonyms
20-Hydroxy-leukotriene B4; 20-hydroxy-LTB4; 20-hydroxy LTB4; 20-OH-LTB4; 20-OH-Leukotriene B4; (5S,6Z,8E,10E,12R,14Z)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoic acid; CHEBI:15646; 79516-82-8; 5S,12R,20-trihydroxy-6Z,8E,10E,14Z-eicosatetraenoic acid; 20-hydroxyleukotriene B4; (5S,12R)-5,12,20-Trihydroxy-(6Z,8E,10E,14Z)-eicosatetraenoic acid; (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyicosa-6,8,10,14-tetraenoate; (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-Trihydroxyeicosa-6,8,10,14-tetraenoate; 5,12,20-Trihete; w-Hydroxy-LTB4
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5280745
ChEBI ID
CHEBI:15646
CAS Number
CAS 79516-82-8
TTD Drug ID
DM84GAQ

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Leukotriene B4 receptor 2 (LTB4R2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
LTB4 DME26RS Human immunodeficiency virus infection 1C62 Phase 2 [3]
Biomed 101 DMQ9KZW Kidney cancer 2C90.0 Phase 1 [3]
ONO-4057 DMNEA78 Inflammatory bowel disease DD72 Discontinued in Phase 2 [4]
CP-105696 DM1C4IN Inflammatory bowel disease DD72 Discontinued in Phase 1 [5]
LY-292728 DMU24HR N. A. N. A. Terminated [6]
LY-255283 DMFIR0S Asthma CA23 Terminated [7]
LY-282210 DMBSFDE Discovery agent N.A. Investigative [6]
(3S,4R)-3-Benzyl-7-isopropyl-chroman-4-ol DMET6IS Discovery agent N.A. Investigative [5]
12S-HETE DMBEZ09 Discovery agent N.A. Investigative [8]
ZK-158252 DMNMD0J Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Leukotriene B4 receptor 2 (LTB4R2) TTVJX54 LT4R2_HUMAN Agonist [2]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3399).
2 A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature. 1997 Jun 5;387(6633):620-4.
3 Diaryl ether/carboxylic acid derivatives of LY255283: Receptor antagonists of leukotriene B4, Bioorg. Med. Chem. Lett. 3(10):1985-1990 (1993).
4 ONO-4057, a novel, orally active leukotriene B4 antagonist: effects on LTB4-induced neutrophil functions. Prostaglandins. 1992 Oct;44(4):261-75.
5 3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor, Bioorg. Med. Chem. Lett. 7(17):2307-2312 (1997).
6 Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4.
7 o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3978-81.
8 Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001 Apr 13;276(15):12454-9.