Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8A1ZU)

Drug Name

6-bromo-5-phenylpyrimidine-2,4(1H,3H)-dione Drug Info

Synonyms

CHEMBL235666; BDBM20076; 6-Bromo-5-phenylpyrimidine-2,4(1H,3H)-dione, 23

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Thymidine phosphorylase (TYMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Uridine	DMQTREB	Depression	6A70-6A7Z	Approved	[2]
5-bromo-6-hydrazinouracil hydrochloride	DMZJE6M	Discovery agent	N.A.	Investigative	[3]
5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil	DMEV0GO	Discovery agent	N.A.	Investigative	[4]
6-chloro-5-phenylpyrimidine-2,4(1H,3H)-dione	DM90JMN	Discovery agent	N.A.	Investigative	[1]
6-chloro-5-heptylpyrimidine-2,4(1H,3H)-dione	DMASFR6	Discovery agent	N.A.	Investigative	[1]
1-(cyclohexyl)methyl-5'-O-tritylinosine	DMS3XUC	Discovery agent	N.A.	Investigative	[5]
1-(cyclopropyl)methyl-5'-O-tritylinosine	DMDU3X7	Discovery agent	N.A.	Investigative	[5]
1-propyl-5'-O-tritylinosine	DM5P01L	Discovery agent	N.A.	Investigative	[5]
1-allyl-5'-O-tritylinosine	DM2J5WH	Discovery agent	N.A.	Investigative	[5]
5-benzyl-6-chloropyrimidine-2,4(1H,3H)-dione	DMCKODQ	Discovery agent	N.A.	Investigative	[1]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Thymidine phosphorylase (TYMP)	TTO0IB8	TYPH_HUMAN	Inhibitor	[1]

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References

1	Discovery of 5-substituted-6-chlorouracils as efficient inhibitors of human thymidine phosphorylase. J Med Chem. 2007 Nov 29;50(24):6016-23.
2	Enzymatic activities of uridine and thymidine phosphorylase in normal and cancerous uterine cervical tissues. Hum Cell. 2007 Nov;20(4):107-10.
3	Design and synthesis of novel 5,6-disubstituted uracil derivatives as potent inhibitors of thymidine phosphorylase. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1335-7.
4	The role of phosphate in the action of thymidine phosphorylase inhibitors: Implications for the catalytic mechanism. Bioorg Med Chem Lett. 2010 Mar 1;20(5):1648-51.
5	5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase. J Med Chem. 2006 Sep 7;49(18):5562-70.