Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8B2WQ)

Drug Name

AN-2718 Drug Info

Synonyms

Boron-based leucyl-tRNA synthetase inhibitor (topical, fungal infections), Anacor

Indication

Disease Entry	ICD 11	Status	REF
Fungal infection	1F29-1F2F	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

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Drug(s) Targeting Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tavaborole	DM3ED1A	Onychomycosis	EE12.1	Approved	[3]
GSK-2251052	DMLFI7Q	Urinary tract infection	GC08	Phase 2	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Staphylococcus Leucyl-tRNA synthetase (Stap-coc leuS)	TT37GL6	SYL_STAAE	Inhibitor	[2]

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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019312)
2	Metalloid compounds as drugs. Res Pharm Sci. 2013 Jul-Sep; 8(3): 145-158.
3	An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site. Science. 2007 Jun 22;316(5832):1759-61.
4	Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections. Antimicrob Agents Chemother. 2015 Jan;59(1):289-98.