Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8CYJ1)

Drug Name

AVP-13358 Drug Info

Synonyms

IgE inhibitors, AVANIR; Allergy/asthma therapeutic, AVANIR

Indication

Disease Entry	ICD 11	Status	REF
Rhinitis	FA20	Phase 1	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Immunoglobulin E (IgE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ligelizumab	DM103O8	Chronic idiopathic urticaria	EB00.1	Phase 3	[3]
MEMP1972A	DMUMCWS	Allergic rhinitis	CA08.0	Phase 2	[4]
Xmab-7195	DME7IVL	Asthma	CA23	Phase 1	[5]
PF-06444752	DM9UZTO	Asthma	CA23	Phase 1	[6]
MEDI4212	DMBI4EN	Asthma	CA23	Phase 1	[7]
TAK-201	DM8S173	Allergy	4A80-4A85	Discontinued in Phase 2	[8]
TEI-9874	DMXM3B4	Allergy	4A80-4A85	Terminated	[9]
IGE-026	DM16S98	Allergic rhinitis	CA08.0	Terminated	[10]
D17.4	DMSON1P	Myasthenia gravis	8C6Y	Investigative	[11]
IGEL1.2	DMOU234	Allergy	4A80-4A85	Investigative	[11]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	AVANIR Reports Positive Interim Phase I Safety Data on Asthma/Allergy Drug Candidate; Potential Asthma/Allergy Product Modulates IgE and Th2 Cytokines Orally
2	Novel 2-(substituted phenyl)benzimidazole derivatives with potent activity against IgE, cytokines, and CD23 for the treatment of allergy and asthma. J Med Chem. 2004 Dec 16;47(26):6451-4.
3	Clinical pipeline report, company report or official report of Novartis.
4	International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 25, No. 4, 2011
5	Clinical pipeline report, company report or official report of Xencor.
6	ClinicalTrials.gov (NCT01723254) A Study To Assess The Safety And Tolerability Of Different Doses Of PF-06444753 And PF-06444752 In Subjects With Allergic Rhinitis. U.S. National Institutes of Health.
7	A novel IgE-neutralizing antibody for the treatment of severe uncontrolled asthma. MAbs. 2014 May-Jun;6(3):756-64.
8	Adecatumumab: an anti-EpCAM monoclonal antibody, from the bench to the bedside. Expert Opin Biol Ther. 2010 Jun;10(6):951-8.
9	Effect of TEI-9874, an inhibitor of immunoglobulin E production, on allergen-induced asthmatic model in rats. Eur J Pharmacol. 2000 Aug 25;402(3):287-95.
10	IgE inhibition as a therapy for allergic disease. Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):112-5.
11	Therapeutic applications of aptamers. Expert Opin Investig Drugs. 2008 Jan;17(1):43-60.