General Information of Drug (ID: DM8E62L)

Drug Name
Sigmoidin F Drug Info
Synonyms
Sigmoidin F; CHEMBL229222; 126005-97-8; AC1L4UEV; AC1Q6NL6; (2,6'-bi-2h-1-benzopyran)-4(3h)-one, 5,7,8'-trihydroxy-2',2'-dimethyl-7'-(3-methyl-2-butenyl)-,(r)-; BDBM50212398; (2R)-5,7-dihydroxy-2-[8-hydroxy-2,2-dimethyl-7-(3-methylbut-2-enyl)chromen-6-yl]-2,3-dihydrochromen-4-one; (2,6'-Bi-2H-1-benzopyran)-4(3H)-one, 5,7,8'-trihydroxy-2',2'-dimethyl-7'-(3-methyl-2-butenyl)-, (R)-
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
164215
CAS Number
CAS 126005-97-8
TTD Drug ID
DM8E62L

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [2]
TRYPAN BLUE DM4NTMO Ophthalmic surgery injury PK97 Approved [3]
URSOLIC ACID DM4SOAW Metabolic syndrome x 5C50-5D2Z Phase 2 [4]
ISIS 113715 DMUPD4G Type-2 diabetes 5A11 Phase 2 [5]
ISIS-PTP1Brx DMJGVXT Type-2 diabetes 5A11 Phase 2 [6]
ERTIPROTAFIB DMJXEV7 Type-2 diabetes 5A11 Terminated [7]
Acetate Ion DMD08RH Discovery agent N.A. Investigative [8]
B-Octylglucoside DMMO75G Discovery agent N.A. Investigative [8]
2-Methyl-2,4-Pentanediol DMD45CU Discovery agent N.A. Investigative [8]
Double Oxidized Cysteine DM6TU84 Discovery agent N.A. Investigative [8]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [1]

References

1 Isoprenylated flavonoids from the stem bark of Erythrina abyssinica. J Nat Prod. 2007 Jun;70(6):1039-42.
2 Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
3 Evans Blue and other dyes as protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1923-6.
4 Cytotoxic and PTP1B inhibitory activities from Erythrina abyssinica. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6745-9.
5 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).
6 Clinical pipeline report, company report or official report of ISIS Pharmaceuticals.
7 2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5357-60.
8 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.