Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8GRJK)

Drug Name

Rapamycin Drug Info

Synonyms

MTOR inhibitors

Indication

Disease Entry	ICD 11	Status	REF
Lymphangioleiomyomatosis	CB07	Approved	[1]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[2]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[2]

Therapeutic Class

Antiviral Agents

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting HUMAN mammalian target of rapamycin (mTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMTXHJ9	Lymphangioleiomyomatosis	CB07	Phase 2	[3]
Everolimus	DM17TYR	Advanced/metastatic breast cancer	2C60	Investigative	[2]
Sapanisertib	DMYZFNH	Breast cancer	2C60-2C65	Investigative	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
HUMAN mammalian target of rapamycin (mTOR)	TT7HQAF	MTOR_HUMAN	Inhibitor	[2]

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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
3	Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2. Cell Discov. 2020 Mar 16;6:14.
4	Prevent COVID-19 Severity by Repurposing mTOR Inhibitors. 2 April 2020