Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8I5UF)

Drug Name

B-5354a Drug Info

Synonyms

B-5354b; B-5354c; Sphingosine kinase inhibitors, Sankyo

Indication

Disease Entry	ICD 11	Status	REF
Arteriosclerosis	BD40	Terminated	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Patented Agent(s)

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Drug(s) Targeting Sphingosine kinase 1 (SPHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenoxodiol	DMBUJVX	Ovarian cancer	2C73	Phase 1/2	[3]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[4]
PMID27539678-Compound-6	DMBKNDE	N. A.	N. A.	Patented	[5]
Methylbenzenesulfonamide derivative 1	DMUNME2	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-12	DMNIKTA	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-10	DM61SR0	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-16	DMMDJH8	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-14	DMZ02LA	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-13	DM1J2V8	N. A.	N. A.	Patented	[5]
PMID27539678-Compound-11	DMIKAJC	N. A.	N. A.	Patented	[5]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

References

1	B-535a, b and c, new sphingosine kinase inhibitors, produced by a marine bacterium; taxonomy, fermentation, isolation, physico-chemical properties and structure determination. J Antibiot (Tokyo). 2000 Aug;53(8):753-8.
2	Characterization of B-5354c, a new sphingosine kinase inhibitor, produced by a marine bacterium. J Antibiot (Tokyo). 2000 Aug;53(8):759-64.
3	Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4	Sphingosine kinase 1 is a potential therapeutic target for nasopharyngeal carcinoma.Oncotarget. 2016 Dec 6;7(49):80586-80598.
5	Sphingosine kinase inhibitors: a review of patent literature (2006-2015).Expert Opin Ther Pat. 2016 Dec;26(12):1409-1416.