Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8L3JU)

Drug Name

Fosclin Drug Info

Synonyms

Fosmidomycin + clindamycin (oral, malaria), Jomaa; Fosmidomycin + clindamycin fixed-dose combination (oral, malaria), Jomaa

Indication

Disease Entry	ICD 11	Status	REF
Malaria	1F40-1F45	Phase 3	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting Plasmodium DOXP reductoisomerase (Malaria DXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fosmidomycin	DM7G0EP	Malaria	1F40-1F45	Approved	[3]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Plasmodium DOXP reductoisomerase (Malaria DXR)	TTLH4J3	DXR_PLAFX	Inhibitor	[2]

------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT00214643) Efficacy of Fosmidomycin-Clindamycin for Treating Malaria in Gabonese Children. U.S. National Institutes of Health.
2	Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children. J Infect Dis. 2004 Mar 1;189(5):901-8.
3	Structural basis of fosmidomycin action revealed by the complex with 2-C-methyl-D-erythritol 4-phosphate synthase (IspC). Implications for the cata... J Biol Chem. 2003 May 16;278(20):18401-7.