Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8LSQP)

Drug Name

LY344864 Drug Info

Synonyms

LY 344864 racemate; LY344864; LY-344864; GTPL21; LY344864 racemate HCl; SCHEMBL7665368; CHEMBL3186179; BDBM85195; GKWHICIUSVVNGX-UHFFFAOYSA-N; BCP23551; PDSP2_001556; PDSP1_001572; HY-13788C; NSC_5311097; CAS_5311097; NCGC00167736-01; 186543-64-6; CS-0022633; L000365; N-(6-dimethylamino-6,7,8,9-tetrahydro-5H-carbazol-3-yl)-4-fluorobenzamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 18971832
TTD Drug ID: DM8LSQP

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Investigative Drug(s)

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Drug(s) Targeting 5-HT 1F receptor (HTR1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[3]
Lasmiditan	DMXLVDT	Migraine	8A80	Approved	[4]
LY-334370	DM43O9N	Migraine	8A80	Phase 2	[5]
5-CT	DM260KD	Discovery agent	N.A.	Investigative	[3]
TFMPP	DMAC8TP	Discovery agent	N.A.	Investigative	[6]
1-naphthylpiperazine	DM6BIWK	Discovery agent	N.A.	Investigative	[3]
BRL-15572	DMM61Y2	Discovery agent	N.A.	Investigative	[7]
2-methyl-5-HT	DM1S5CB	N. A.	N. A.	Investigative	[6]
alpha-methyl-5-HT	DMCAYXF	Discovery agent	N.A.	Investigative	[6]
WAY-466	DMMOH51	Discovery agent	N.A.	Investigative	[8]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1F receptor (HTR1F)	TT0MI3F	5HT1F_HUMAN	Agonist	[2]

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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 21).
2	5-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein. J Pharmacol Exp Ther. 1999 Sep;290(3):935-9.
3	Cloning and characterization of the guinea pig 5-HT1F receptor subtype: a comparison of the pharmacological profile to the human species homolog. Neuropharmacology. 1997 Apr-May;36(4-5):569-76.
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2019
5	Selective seratonin 1F (5-HT(1F)) receptor agonist LY334370 for acute migraine: a randomised controlled trial. Lancet. 2001 Oct 13;358(9289):1230-4.
6	Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):408-12.
7	SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 1997 Sep;356(3):312-20.
8	Discovery of 5-arylsulfonamido-3-(pyrrolidin-2-ylmethyl)-1H-indole derivatives as potent, selective 5-HT6 receptor agonists and antagonists. J Med Chem. 2005 Jan 27;48(2):353-6.