Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8OYI4)

Drug Name
Platinum IV complexe 1 Drug Info
Synonyms PMID26394986-Compound-69
Cross-matching ID
TTD Drug ID
DM8OYI4

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Patented Agent(s)
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Signal transducer and activator of transcription 5 (STAT5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID26394986-Compound-10 DMP8RQ4 N. A. N. A. Patented [1]
PMID26394986-Compound-56 DMPNJ4X N. A. N. A. Patented [1]
Indirubin derivative 1 DMB8673 N. A. N. A. Patented [1]
PMID26394986-Compound-57 DMILUT8 N. A. N. A. Patented [1]
Drug(s) Targeting Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [2]
Napabucasin DMDZ6Q3 Colorectal cancer 2B91.Z Phase 3 [3]
Golotimod DMKZN3A Immune System disease 4A01-4B41 Phase 2 [4]
NT219 DMOYS1N Solid tumour/cancer 2A00-2F9Z Phase 1/2 [5]
WP-1066 DMUGHWR Recurrent glioblastoma 2A00.00 Phase 1/2 [3]
Atiprimod DM84YEC Multiple myeloma 2A83 Phase 1/2 [6]
OPB-31121 DM6VGO3 Hepatocellular carcinoma 2C12.02 Phase 1/2 [7]
IMX-110 DMNHZS4 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [3]
GLG-801 DMY1CP9 Chronic lymphocytic leukaemia 2A82.0 Phase 1/2 [3]
OPB-51602 DM760FA Solid tumour/cancer 2A00-2F9Z Phase 1 [8]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Signal transducer and activator of transcription 1 (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
PMID26394986-Compound-10 DMP8RQ4 N. A. N. A. Patented [1]
Oxazole derivative 1 DM7Y2RL N. A. N. A. Patented [1]
Peptidomimetic analog 5 DMF0DE2 N. A. N. A. Patented [1]
Peptide analog 8 DMFG7A8 N. A. N. A. Patented [1]
AVT-02 UE DM8NA4M Skin infection 1F28-1G0Z Discontinued in Phase 2 [9]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Signal transducer and activator of transcription 1 (STAT1) TTN7R6K STAT1_HUMAN Inhibitor [1]
Signal transducer and activator of transcription 3 (STAT3) TTH8FZW STAT3_HUMAN Inhibitor [1]
Signal transducer and activator of transcription 5 (STAT5) TTLRFIH STA5A_HUMAN; STA5B_HUMAN Inhibitor [1]

References

1 A STAT inhibitor patent review: progress since 2011.Expert Opin Ther Pat. 2015;25(12):1397-421.
2 Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells. Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):21-4.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 National Cancer Institute Drug Dictionary (drug id 617379).
5 Clinical pipeline report, company report or official report of Purple Biotech.
6 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
7 OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 2013 Jul 10;335(1):145-52.
8 Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Ann Oncol. 2015 May;26(5):998-1005.
9 Avontec Announces Results of a Multiple Dose Clinical Phase I Study with Its Drug Candidate AVT-02 UE Ointment After Topical Treatment in Male Healthy Volunteers. Avontec. 2008.