Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8QM5U)

Drug Name
Anidulafungin Drug Info
Synonyms Ecalta; Eraxis; Anidulafungin [USAN:INN]; Ecalta (TN); Eraxis (TN); LY-303366; V-Echinocandin; VER-002
Indication
Disease Entry ICD 11 Status REF
Aspergillosis 1F20 Approved [1]
Candidiasis 1F23 Approved [2]
Convulsion 8A68.Z Approved [3]
Mycosis fungoides 2B01 Approved [1]
Neuroaspergillosis Approved [1]
Candidemia 1F23.3Y Investigative [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [4]
Esophageal candidiasis Investigative [1]
Therapeutic Class
Antifungal Agents
Cross-matching ID
PubChem CID
166548
ChEBI ID
CHEBI:55346
CAS Number
CAS 166663-25-8
TTD Drug ID
DM8QM5U

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Fungal 1,3-beta-glucan synthase (Fung GSC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Caspofungin DMGQIPT Candidiasis 1F23 Approved [6]
Micafungin DM6Y3AN Aspergillosis 1F20 Approved [7]
Rezafungin DMQ4CSX Candidiasis 1F23 Approved [8]
Ibrexafungerp DMK1IPV Vulvovaginal Candidiasis 1F23.10 Approved [9]
L-733560 DMYZPJU Aspergillosis 1F20 Terminated [10]
Drug(s) Targeting COVID-19 RNA-directed RNA polymerase (RdRp)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [11]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [12]
Penciclovir DMOUMDV Herpes simplex labialis 1F00.01 Approved [11]
Favipiravir DMBZ27L Influenza virus infection 1E30-1E32 Registered [13]
Galidesivir DMG9C4I Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 1 Trial [14]
Suramin DMTOUY9 African trypanosomiasis 1F51 Phase 1 [4]
⏷ Show the Full List of 6 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fungal 1,3-beta-glucan synthase (Fung GSC2) TT0SFXH FKS2_YEAST Modulator [5]
COVID-19 RNA-directed RNA polymerase (RdRp) TTV1095 R1AB_SARS2 (4393-5324) Inhibitor [4]

References

1 Anidulafungin FDA Label
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Echinocandins: pharmacokinetic and therapeutic issues. Curr Med Res Opin. 2009 Jul;25(7):1741-50.
4 Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh
5 2006 drug approvals: finding the niche. Nat Rev Drug Discov. 2007 Feb;6(2):99-101.
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
7 An immunomodulatory activity of micafungin in preclinical aspergillosis. J Antimicrob Chemother. 2014 Apr;69(4):1065-74.
8 Antifungal drugs: What brings the future?. Med Mycol. 2019 Jun 1;57(Supplement_3):S328-S343.
9 Pharmacodynamic target evaluation of a novel oral glucan synthase inhibitor, SCY-078 (MK-3118), using an in vivo murine invasive candidiasis model. Antimicrob Agents Chemother. 2015 Feb;59(2):1265-72.
10 Discovery of Novel Antifungal (1,3)--d-Glucan Synthase Inhibitors
11 Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 2020 Mar;30(3):269-271.
12 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
13 Favipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial. medRxiv. Posted April 15, 2020.
14 BioCryst Begins Clinical Trial with Galidesivir for Treatment of Patients with COVID-19