General Information of Drug (ID: DM8RNSB)

Drug Name
WP1220 Drug Info
Synonyms
mol4239; MOL-4239; PTN9LJL6PY; UNII-PTN9LJL6PY; WP-1220; 2,4-Pentadienamide, 5-(6-bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-, (2E,4E)-; 1204306-34-2; SCHEMBL862248; SCHEMBL1316581; CHEMBL4594434; (2E,4E)-5-(6-Bromo-2-pyridinyl)-2-cyano-N-((1S)-1-phenylethyl)-2,4-pentadienamide; (2E,4E)-5-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]penta-2,4-dienamide
Indication
Disease Entry ICD 11 Status REF
Cutaneous T-cell lymphoma 2B01 Phase 1 [1]
Cross-matching ID
PubChem CID
44554865
CAS Number
CAS 1204306-34-2
TTD Drug ID
DM8RNSB

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [3]
Napabucasin DMDZ6Q3 Colorectal cancer 2B91.Z Phase 3 [4]
Golotimod DMKZN3A Immune System disease 4A01-4B41 Phase 2 [5]
NT219 DMOYS1N Solid tumour/cancer 2A00-2F9Z Phase 1/2 [6]
WP-1066 DMUGHWR Recurrent glioblastoma 2A00.00 Phase 1/2 [4]
Atiprimod DM84YEC Multiple myeloma 2A83 Phase 1/2 [7]
OPB-31121 DM6VGO3 Hepatocellular carcinoma 2C12.02 Phase 1/2 [8]
IMX-110 DMNHZS4 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [4]
GLG-801 DMY1CP9 Chronic lymphocytic leukaemia 2A82.0 Phase 1/2 [4]
OPB-51602 DM760FA Solid tumour/cancer 2A00-2F9Z Phase 1 [9]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Signal transducer and activator of transcription 3 (STAT3) TTH8FZW STAT3_HUMAN Inhibitor [2]

References

1 ClinicalTrials.gov (NCT04702503) Study of WP1220 for the Treatment of Adult Subjects With Cutaneous T-Cell Lymphoma (CTCL). U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of Moleculin Biotech.
3 Effects of acitretin on the expression of signaling pathway-related genes in epidermal squamous-cell carcinoma cells. Zhonghua Zhong Liu Za Zhi. 2006 Jan;28(1):21-4.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 National Cancer Institute Drug Dictionary (drug id 617379).
6 Clinical pipeline report, company report or official report of Purple Biotech.
7 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
8 OPB-31121, a novel small molecular inhibitor, disrupts the JAK2/STAT3 pathway and exhibits an antitumor activity in gastric cancer cells. Cancer Lett. 2013 Jul 10;335(1):145-52.
9 Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies. Ann Oncol. 2015 May;26(5):998-1005.