General Information of Drug (ID: DM8TBQ9)

Drug Name
Dihexan-3-yl 5-(hydroxymethyl)isophthalate Drug Info
Synonyms CHEMBL523053; dihexan-3-yl 5-(hydroxymethyl)isophthalate; SCHEMBL13625642
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44186618
TTD Drug ID
DM8TBQ9

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Investigative Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [2]
Sotrastaurin acetate DME53YS Renal transplantation NE84 Phase 2 [3]
PMID28460551-Compound-3 DMA1FRM N. A. N. A. Patented [4]
ISIS 3521 DMZFS69 N. A. N. A. Discontinued in Phase 2 [5]
BALANOL DMDLN9E N. A. N. A. Terminated [6]
RO-320432 DMFZ1YW N. A. N. A. Terminated [7]
LY-317644 DMM20PI N. A. N. A. Terminated [8]
Acteoside DM0YHKB Nephritis GB40 Terminated [9]
RO-316233 DMAGLPW Discovery agent N.A. Investigative [10]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole DMN9YOB Discovery agent N.A. Investigative [11]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [6]
Bisindolylmaleimide-I DMOQJZC Discovery agent N.A. Investigative [12]
LY-326449 DMN53M4 Discovery agent N.A. Investigative [13]
PROSTRATIN DM1HMJ5 Human immunodeficiency virus infection 1C62 Investigative [14]
8-Octyl-benzolactam-V9 DM4Z15M Discovery agent N.A. Investigative [15]
Go 6983 DMKVTZN Discovery agent N.A. Investigative [16]
Diheptan-3-yl 5-(hydroxymethyl)isophthalate DMBAY7P Discovery agent N.A. Investigative [1]
ISIS 10310 DMT6H9S Discovery agent N.A. Investigative [17]
ISIS 17252 DMW40NK Discovery agent N.A. Investigative [18]
ISIS 10303 DM205TE Discovery agent N.A. Investigative [17]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PKC-delta messenger RNA (PRKCD mRNA) TT7A1BO KPCD_HUMAN Inhibitor [1]
Protein kinase C alpha (PRKCA) TTFJ8Q1 KPCA_HUMAN Inhibitor [1]

References

1 Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C. J Med Chem. 2009 Jul 9;52(13):3969-81.
2 Polo-like kinase inhibitor Ro5203280 has potent antitumor activity in nasopharyngeal carcinoma.Mol Cancer Ther. 2013 Aug;12(8):1393-401.
3 Emerging drugs for psoriasis. Expert Opin Emerg Drugs. 2009 Mar;14(1):145-63.
4 Cancer stem cell (CSC) inhibitors: a review of recent patents (2012-2015).Expert Opin Ther Pat. 2017 Jul;27(7):753-761.
5 Phase II study of PKC-alpha antisense oligonucleotide aprinocarsen in combination with gemcitabine and carboplatin in patients with advanced non-small cell lung cancer.Lung Cancer.2006 May;52(2):173-80.
6 Evaluation of differential hypoxic cytotoxicity and electrochemical studies of nitro 5-deazaflavins, Bioorg. Med. Chem. Lett. 5(18):2155-2160 (1995).
7 Bisindolylmaleimide inhibitors of protein kinase C. Further conformational restriction of a tertiary amine side chain, Bioorg. Med. Chem. Lett. 4(11):1303-1308 (1994).
8 Synthesis of bisindolylmaleimide macrocycles, Bioorg. Med. Chem. Lett. 5(18):2093-2096 (1995).
9 Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCalpha-inhibitory activity. J Nat Prod. 1998 Nov;61(11):1410-2.
10 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.
11 Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole. J Med Chem. 2004 Dec 2;47(25):6239-47.
12 Protein kinase C epsilon regulates gamma-aminobutyrate type A receptor sensitivity to ethanol and benzodiazepines through phosphorylation of gamma2... J Biol Chem. 2007 Nov 9;282(45):33052-63.
13 (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H... J Med Chem. 1996 Jul 5;39(14):2664-71.
14 A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1. J Med Chem. 1992 May 29;35(11):1978-86.
15 Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta. J Med Chem. 2006 May 4;49(9):2681-8.
16 Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 1996 Aug 26;392(2):77-80.
17 US patent application no. 5,959,096, Antisense oligonucleotides against human protein kinase C.
18 US patent application no. 6,235,723, Antisense oligonucleotide modulation of human protein kinase C-.delta. expression.