General Information of Drug (ID: DM8U23L)

Drug Name
GGTI-2418 Drug Info
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Cross-matching ID
PubChem CID
11539477
CAS Number
CAS 501010-06-6
TTD Drug ID
DM8U23L

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lonafarnib DMGM2Z6 Hutchinson-Gilford progeria syndrome LD2B Approved [3]
Zarnestra DMF30HL Acute myeloid leukaemia 2A60 Phase 3 [4]
L-778123 DMWSC5L Lymphoma 2A80-2A86 Phase 1 [5]
BMS214662 DM5M48F Non-small-cell lung cancer 2C25.Y Phase 1 [6]
L-745631 DM4UP7R Solid tumour/cancer 2A00-2F9Z Terminated [7]
ABT-839 DM4UN9A Non-small-cell lung cancer 2C25.Y Terminated [8]
MANUMYCIN A DM1SWOY N. A. N. A. Terminated [9]
SCH-44342 DMUL4VX N. A. N. A. Terminated [10]
RPR-113829 DMJ63GW N. A. N. A. Terminated [11]
RPR-114334 DMAIJT6 N. A. N. A. Terminated [11]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Farnesyl protein transferase (Ftase) TTXQKM3 FNTA_HUMAN; FNTB_HUMAN Modulator [2]

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030147)
2 Company report (Prescient)
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
4 Tipifarnib in the treatment of newly diagnosed acute myelogenous leukemia. Biologics. 2008 Sep;2(3):491-500.
5 Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein trans... Mol Cancer Ther. 2002 Jul;1(9):747-58.
6 Farnesyltransferase inhibitor BMS-214662 induces apoptosis in B-cell chronic lymphocytic leukemia cells. Leukemia. 2004 Oct;18(10):1599-604.
7 Ras farnesyltransferase: a new therapeutic target. J Med Chem. 1997 Sep 12;40(19):2971-90.
8 Aryl tetrahydropyridine inhibitors of farnesyltransferase: glycine, phenylalanine and histidine derivatives. Bioorg Med Chem Lett. 2003 Apr 7;13(7):1359-62.
9 A novel metal-chelating inhibitor of protein farnesyltransferase. Bioorg Med Chem Lett. 2003 May 5;13(9):1523-6.
10 Tricyclic farnesyl protein transferase inhibitors: crystallographic and calorimetric studies of structure-activity relationships. J Med Chem. 1999 Jun 17;42(12):2125-35.
11 Novel conformationally extended naphthalene-based inhibitors of farnesyltransferase. J Med Chem. 1997 Jun 6;40(12):1763-7.