Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8UOKE)

Drug Name
US9096594, 3 Drug Info
Synonyms BDBM173195; US9096594, 3
Cross-matching ID
PubChem CID
118797815
TTD Drug ID
DM8UOKE

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
Drug Status:
Clinical Trial Drug(s)
Preclinical Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Casein kinase I alpha (CSNK1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BTX-A51 DMC8XHQ Advanced solid tumour 2A00-2F9Z Phase 1 [2]
IC261 DMXB95R Pancreatic cancer 2C10 Preclinical [3]
D-4476 DMHD3R8 Chronic lymphocytic leukaemia 2A82.0 Preclinical [4]
PMID24900428C14 DMU4BL2 Discovery agent N.A. Investigative [5]

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Casein kinase I alpha (CSNK1A1) TTFQEMX KC1A_HUMAN Inhibitor [1]

References

1 Kinase inhibitors and methods of use thereof. US9096594.
2 Clinical pipeline report, company report or official report of BioTheryX.
3 Crystal structure of a conformation-selective casein kinase-1 inhibitor. J Biol Chem. 2000 Jun 30;275(26):20052-60.
4 Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization. Eur J Med Chem. 2012 Oct;56:30-8.
5 Structure-Based Design of Potent and Selective CK1gamma Inhibitors. ACS Med Chem Lett. 2012 Oct 18;3(12):1059-64.