Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8XHJG)

Drug Name

A-893 Drug Info

Synonyms

1868232-32-9; (R)-N-cyclohexyl-3-((3,4-dichlorophenethyl)amino)-N-(2-((2-hydroxy-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethyl)amino)ethyl)propanamide; CHEMBL3590526; N-Cyclohexyl-N~3~-[2-(3,4-Dichlorophenyl)ethyl]-N-(2-{[(2r)-2-Hydroxy-2-(3-Oxo-3,4-Dihydro-2h-1,4-Benzoxazin-8-Yl)ethyl]amino}ethyl)-Beta-Alaninamide; SCHEMBL17476248; EX-A2769; BDBM50095537; AKOS030235552; ZINC230499113; ACN-037539; AC-29886; HY-19563; CS-0015655; Q27454706; 4GQ; N-Cyclohexyl-3-[2-(3,4-dichlorophenyl)ethylamino]-N-[2-[[(2R)-2-hydroxy-2-(3-oxo-4H-1,4-benzoxazin-8-yl)ethyl]amino]ethyl]propanamide

Indication

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Preclinical	[1]

Cross-matching ID

PubChem CID: 91757965
TTD Drug ID: DM8XHJG

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Preclinical Drug(s)

Download the Complete Related Drug List

Drug(s) Targeting SET and MYND domain-containing protein 2 (SMYD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AZ505	DMKQ20J	Solid tumour/cancer	2A00-2F9Z	Preclinical	[2]
LLY-507	DMNOE1M	Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]
EPZ032597	DMHU742	Solid tumour/cancer	2A00-2F9Z	Preclinical	[4]
EPZ033294	DMDO6NZ	Solid tumour/cancer	2A00-2F9Z	Preclinical	[4]
BAY 598	DMWH19X	Discovery agent	N.A.	Preclinical	[5]
------------------------------------------------------------------------------------

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
SET and MYND domain-containing protein 2 (SMYD2)	TT7YJFO	SMYD2_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

References

1	Discovery of A-893, A New Cell-Active Benzoxazinone Inhibitor of Lysine Methyltransferase SMYD2. ACS Med Chem Lett. 2015 Apr 29;6(6):695-700.
2	Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2714).
4	Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
5	Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2. J Med Chem. 2016 May 26;59(10):4578-600.