Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM94RJW)

Drug Name

SPT Drug Info

Synonyms

8-Pspt; 8-(p-Sulfophenyl)theophylline hydrate; MLS000859938; CHEMBL1697922; HMS3373H03; HMS2230M12; AKOS024360233; SMR000326799; 8-(p-Sulfophenyl)theophylline hydrate, solid; ST50990065; 4-(1,3-dimethyl-2,6-dioxo-1,3-dihydropurin-8-yl)benzenesulfonic acid, hydrate; 4-(1,3-Dimethyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl)benzenesulfonic acid hemihydrate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 18528136
TTD Drug ID: DM94RJW

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

Investigative Drug(s)

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Drug(s) Targeting Adenosine receptor (ADOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[2]
NIR178	DMPER4A	Non-hodgkin lymphoma	2B33.5	Phase 2	[3]
DIADENOSINE TETRAPHOSPHATE	DMTJOEL	Cardiac arrhythmias	BC9Z	Phase 2	[4]
M-216765	DMUIGM3	Hypertension	BA00-BA04	Terminated	[5]
GNF-PF-2224	DM26UKN	Discovery agent	N.A.	Investigative	[6]
8-sulfophenyl theophylline	DMOHB3Z	Discovery agent	N.A.	Investigative	[6]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

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Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine receptor (ADOR)	TTSLI08	NOUNIPROTAC	Antagonist	[1]

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References

1	Pretreatment with angiotensin II activates protein kinase C and limits myocardial infarction in isolated rabbit hearts. J Mol Cell Cardiol. 1995 Mar;27(3):883-92.
2	Emerging adenosine receptor agonists. Expert Opin Emerg Drugs. 2007 Sep;12(3):479-92.
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	Negative chronotropic and inotropic effects exerted by diadenosine hexaphosphate (AP6A) via A1-adenosine receptors. Br J Pharmacol. 1996 Nov;119(5):835-44.
5	US patent application no. 2010,0009,934, Beta adrenergic receptor agonists for the treatment of b-cell proliferative disorders.
6	Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J Invest Dermatol. 2001 Dec;117(6):1594-600.