Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9C8FP)

Drug Name

I-BRD9 Drug Info

Synonyms

GSK602; compound 45 [PMID 25856009]

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Investigative Drug(s)

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Drug(s) Targeting Bromodomain-containing protein 9 (BRD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LP99	DMTZYQ3	Discovery agent	N.A.	Investigative	[2]
BI 7273	DMI3ANC	Acute myeloid leukaemia	2A60	Investigative	[3]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain-containing protein 9 (BRD9)	TTR7L5Y	BRD9_HUMAN	Inhibitor	[1]

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References

1	Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J Med Chem. 2016 Feb 25;59(4):1425-39.
2	LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21.
3	Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor. J Med Chem. 2016 May 26;59(10):4462-75.