Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM9DFBU)

Drug Name
BI 764524 Drug Info
Indication
Disease Entry ICD 11 Status REF
Diabetic retinopathy 9B71.0 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM9DFBU

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Semaphorin-3A (SEMA3A) TTVKD3S SEM3A_HUMAN Not Available [2]

References

1 ClinicalTrials.gov (NCT04424290) A First-in Human Trial to Study Safety and Tolerability of Single Rising Intravitreal dOses (Open Label, Non-randomized, Uncontrolled) and in Addition the Early Biological Response of Multiple intravitReal Dosing (Single-masked, raNdomized, Sham-controlled) of BI 764524 in panretinaL Photocoagulation (PRP) Treated proLiferative Diabetic Retinopathy (PDR) Patients With Diabetic Macular Ischemia (DMI) - the HORNBILL Study. U.S.National Institutes of Health.
2 HORNBILL: a phase I/IIa trial examining the safety, tolerability and early response of BI 764524 in patients with diabetic retinopathy and diabetic macular ischaemia-rationale, study design and protocol. Trials. 2022 Aug 17;23(1):669.